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TitleAntibacterial and antioxidant activities of Derriobtusone A isolated from Lonchocarpus obtusus
Author(s)Vasconcelos, Mayron Alves
Arruda, Francisco Vassiliepe Sousa
Alencar, Daniel Barroso de
Sampaio, Silvana Saker
Albuquerque, Maria Rose Jane Ribeiro
Santos, Hélcio Silva dos
Bandeira, Paulo Nogueira
Pessoa, Otília Deusdênio Loiola
Cavada, Benildo Sousa
Henriques, Mariana
Pereira, Maria Olívia
Teixeira, Edson Holanda
Issue date2014
PublisherHindawi Publishing Corporation
JournalBiomed Research International
Abstract(s)This study evaluated the effect of derriobtusone A, a flavonoid isolated from Lonchocarpus obtusus, on two important pathogenic bacteria, Staphylococcus aureus and Escherichia coli, as well as its antioxidant activity and toxicity. Planktonic growth assays were performed, and the inhibition of biofilm formation was evaluated. In addition, antioxidant activity was assessed by DPPH radical scavenging assay, ferrous ion chelating assay, ferric-reducing antioxidant power assay, and β-carotene bleaching assay. Toxicity was evaluated by the brine shrimp lethality test. Results showed that derriobtusone A completely inhibited the planktonic growth of S. aureus at 250 and 500 μg/mL; however, it did not have the same activity on E. coli. Derriobtusone A reduced the biomass and colony-forming unit (cfu) of S. aureus biofilm at concentrations of 250 and 500 μg/mL. In various concentrations, it reduced the biofilm biomass of E. coli, and, in all concentrations, it weakly reduced the cfu. Derriobtusone A showed highly efficient antioxidant ability in scavenging DPPH radical and inhibiting β-carotene oxidation. The compound showed no lethality to Artemia sp. nauplii. In conclusion, derriobtusone A may be an effective molecule against S. aureus and its biofilm, as well as a potential antioxidant compound with no toxicity.
Publisher version
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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