Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/31446

TitleDevelopment and characterization of PLA nanoparticles as carriers for topical delivery
Author(s)Fernandes, Bruno Pacheco
Silva, Raquel
Gomes, A. C.
Paulo, Artur Cavaco
Issue date25-May-2014
CitationFernandes, Bruno; Silva, Raquel; Gomes, A. C.; Paulo, Artur Cavaco, Development and characterization of PLA nanoparticles as carriers for topical delivery. IPFB2014 - 8th International Conference on Polymer and Fiber Biotechnology. Braga, Portugal, May 25-27, 2014.
Abstract(s)Nanoparticles are seen today as one of the best approaches for the delivery of drugs into the skin. Poly (Lactic Acid) (PLA) is biocompatible and biodegradable and already approved for clinical use. Thus, this work aimed to study the effect of several parameters on the properties of PLA nanoparticles (PLA-NPs) intended for topical delivery. The yield of nanoparticles formation and entrapment efficiencies of lipophilic and hydrophilic model compounds in PLA-NPs were assessed. We evaluated the effects of mechanical stirring, solvent composition and presence of tri-bloc polymers on the protocol for the production of PLA-NPs. The best protocol provided a monodispersed population of non-cytotoxic spherical particles of !150 nm and a yield of nanoparticles formation of !90%. This formulation also proved to be efficient in the encapsulation of lipophilic and hydrophilic model compounds (>80%). The best protocol for the production of PLA-NPs includes a nanoprecipitation step, which is easily up scalable.
TypeAbstract
URIhttp://hdl.handle.net/1822/31446
Publisher versionhttp://ipfb2014.wix.com/ipfb2014
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Resumos em Livros de Atas / Abstracts in Proceedings

Files in This Item:
File Description SizeFormat 
document_18623_1.pdf92,12 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID