Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/31441

TitleTime-dependent effect of tamoxifen on melanogenesis in normal human melanocytes
Author(s)Matamá, Maria Teresa
Guimarães, Diana Isabel Pereira
Costa, Cristiana
Paulo, Artur Cavaco
Gomes, A. C.
Issue date25-May-2014
CitationMatamá, Maria Teresa; Guimarães, Diana; Costa, Cristiana; Paulo, Artur Cavaco; Gomes, A. C., Time-dependent effect of tamoxifen on melanogenesis in normal human melanocytes. IPFB2014 - 8th International Conference on Polymer and Fiber Biotechnology. Braga, Portugal, May 25-27, 2014.
Abstract(s)In medical literature, occasional case reports describe gray hair re-pigmentation in patients after administration of certain drugs, such as tamoxifen, supporting the possibility of reversing pigmentation loss associated with ageing. This work aimed to study, in vitro, the effect on melanin production in primary human melanocytes of tamoxifen, an antagonist of the estrogen receptor in breast tissue, and of its most bioactive derivative, 4-hydroxy-tamoxifen. Adult normal human epidermal melanocytes (NHEM) were exposed to physiological concentrations of tamoxifen and 4-hydroxy-tamoxifen for 72 hours. The results showed that tamoxifen and 4HO-tamoxifen treatments promoted melanin extrusion. The transcript levels of genes coding for premelanosome protein and melan- A, directly related to skin and hair pigmentation, showed an increased tendency upon tamoxifen and 4-hydroxy-tamoxifen treatment. Induction of catalase gene expression in NHEM points towards a promelanogenic effect mediated by reactive oxygen species. According to the results, these compounds seem to act as melanogenesis stimulators at a molecular level. Our data suggests that SERMs might be a new tool for increasing melanogenesis and might be of great interest for topical formulations in cosmetic industry.
TypeAbstract
URIhttp://hdl.handle.net/1822/31441
Publisher versionhttp://ipfb2014.wix.com/ipfb2014
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Resumos em Livros de Atas / Abstracts in Proceedings

Files in This Item:
File Description SizeFormat 
document_18631_1.pdf103,09 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID