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TitleNatural polymers for the microencapsulation of cells
Author(s)Gasperini, Luca
Mano, J. F.
Reis, R. L.
KeywordsCell encapsulation
Natural polymers
Issue dateSep-2014
PublisherThe Royal Society
JournalJournal of The Royal Society Interface
CitationGasperini L., Mano J. F., Reis R. L. Natural polymers for the microencapsulation of cells, Journal of The Royal Society Interface, Vol. 11, Issue 100, doi:10.1098/​rsif.2014.0817, 2014
Abstract(s)The encapsulation of living mammalian cells within a semi-permeable hydrogel matrix is an attractive procedure for many biomedical and biotechnological applications, such as xenotransplantation, maintenance of stem cell phenotype and bioprinting of three-dimensional scaffolds for tissue engineering and regenerative medicine. In this review, we focus on naturally derived polymers that can form hydrogels under mild conditions and that are thus capable of entrapping cells within controlled volumes. Our emphasis will be on polysaccharides and proteins, including agarose, alginate, carrageenan, chitosan, gellan gum, hyaluronic acid, collagen, elastin, gelatin, fibrin and silk fibroin. We also discuss the technologies commonly employed to encapsulate cells in these hydrogels, with particular attention on microencapsulation.
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AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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