Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/30985
Registo completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Pandis, C. | por |
dc.contributor.author | Trujillo, S. | por |
dc.contributor.author | Matos, Joana | por |
dc.contributor.author | Madeira, S. | por |
dc.contributor.author | Rodenas Rochina, Joaquín | por |
dc.contributor.author | Kripotou, S. | por |
dc.contributor.author | Kyritsis, A. | por |
dc.contributor.author | Mano, J. F. | por |
dc.contributor.author | Ribelles, J. L. Gómez | por |
dc.date.accessioned | 2014-11-18T16:33:50Z | - |
dc.date.available | 2014-11-18T16:33:50Z | - |
dc.date.issued | 2015 | - |
dc.date.submitted | 2014-11 | - |
dc.identifier.issn | 1616-5195 (online) | por |
dc.identifier.uri | https://hdl.handle.net/1822/30985 | - |
dc.description.abstract | A novel approach to reinforce polymer porous membranes is presented. In the prepared hybrid materials, the inorganic phase of silica is synthesized in-situ and inside the pores of aminolyzed polylactic acid (PLA) membranes by sol-gel reactions using tetraethylorthosilicate (TEOS) and glycidoxypropyltrimethoxysilane (GPTMS) as precursors. The hybrid materials present a porous structure with a silica layer covering the walls of the pores while GPTMS serves also as coupling agent between the organic and inorganic phase. The adjustment of silica precursors ratio allows the modulation of the thermomechanical properties. Culture of mesenchymal stem cells on these supports in osteogenic medium shows the expression of characteristic osteoblastic markers and the mineralization of the extracellular matrix. | por |
dc.description.sponsorship | The research project is implemented within the framework of the Action "Supporting Postdoctoral Researchers" of the Operational Program "Education and Lifelong Learning'' (Action's Beneficiary: General Secretariat for Research and Technology), and is co-financed by the European Social Fund (ESF) and the Greek State, Grant No.: NARGEL-PE5(2551). J.R.R. acknowledges funding of his PhD by the Generalitat Valenciana through VALi+d grant (ACIF/2010/238). J.F.M. thanks the Portuguese Foundation for Science and Technology (FCT) for financial support through the PTDC/FIS/115048/2009 project. J.L.G.R. acknowledges the support of the Ministerio de Economia y Competitividad, MINECO, through theMAT2013-46467-C4-1-R project. CIBER-BBN is an initiative funded by the VI National R&D&I Plan 2008-2011, Iniciativa Ingenio 2010, Consolider Program, CIBER Actions and financed by the Instituto de Salud Carlos III with the assistance from the European Regional Development Fund. | por |
dc.language.iso | eng | por |
dc.publisher | Wiley-VCH Verlag | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/115048/PT | - |
dc.rights | openAccess | por |
dc.subject | Organic–inorganic hybrid composites | por |
dc.subject | porosity | por |
dc.subject | Proliferation and osteoblastic differentiation of cells | por |
dc.subject | Sol–gel processes | por |
dc.subject | Thermomechanical properties | por |
dc.title | Porous polylactic acid-silica hybrids: preparation, characterization, and study of mesenchymal stem cell osteogenic differentiation | por |
dc.type | article | - |
dc.peerreviewed | yes | por |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/mabi.201400339/full | por |
dc.comments | http://www.3bs.uminho.pt/node/18163 | por |
sdum.publicationstatus | published | por |
oaire.citationStartPage | 1 | por |
oaire.citationEndPage | 13 | por |
oaire.citationIssue | 2 | por |
oaire.citationTitle | Macromolecular Bioscience | por |
oaire.citationVolume | 15 | por |
dc.date.updated | 2014-11-11T14:53:58Z | - |
dc.identifier.doi | 10.1002/mabi.201400339 | - |
dc.identifier.pmid | 25303745 | por |
dc.subject.wos | Science & Technology | por |
sdum.journal | Macromolecular Bioscience | por |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
18163-Porous Polylactic Acid–Silica Hybrids.pdf | 1,59 MB | Adobe PDF | Ver/Abrir |