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TitlePorous polylactic acid-silica hybrids : preparation, characterization, and study of mesenchymal stem cell osteogenic differentiation
Author(s)Pandis, C.
Trujillo, S.
Matos, Joana
Madeira, S.
Rodenas Rochina, Joaquín
Kripotou, S.
Kyritsis, A.
Mano, J. F.
Ribelles, J. L. Gómez
KeywordsOrganic–inorganic hybrid composites
Proliferation and osteoblastic differentiation of cells
Sol–gel processes
Thermomechanical properties
Issue date2015
PublisherWiley-VCH Verlag
JournalMacromolecular Bioscience
Abstract(s)A novel approach to reinforce polymer porous membranes is presented. In the prepared hybrid materials, the inorganic phase of silica is synthesized in-situ and inside the pores of aminolyzed polylactic acid (PLA) membranes by sol-gel reactions using tetraethylorthosilicate (TEOS) and glycidoxypropyltrimethoxysilane (GPTMS) as precursors. The hybrid materials present a porous structure with a silica layer covering the walls of the pores while GPTMS serves also as coupling agent between the organic and inorganic phase. The adjustment of silica precursors ratio allows the modulation of the thermomechanical properties. Culture of mesenchymal stem cells on these supports in osteogenic medium shows the expression of characteristic osteoblastic markers and the mineralization of the extracellular matrix.
ISSN1616-5195 (online)
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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