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TitleDevelopment of alginate-based hydrogels/cryogels by gelation under pressure
Author(s)Barros, Alexandre A.
Quraishi, Sakeena
Martins, Marta
Raman, S. P.
Gurikov, Pavel
Smirnova, Irina
Duarte, Ana Rita C.
Reis, R. L.
KeywordsAlginate-based biomaterials
co2 gelation
Issue dateJun-2014
JournalJournal of Tissue Engineering and Regenerative Medicine
CitationBarros A. A., Quraishi S., Martins M., Raman S. P., GuriKov P., Smirnova I., Duarte A. R. C., Reis R. L. Development of alginate-based hydrogels/cryogels by gelation under pressure, Termis EU 2014, 2014
Abstract(s)A tissue-engineered polymeric scaffold should provide suitable macroporous structure similar to that of extracellular matrix which can induce cellular activities and guide tissue regeneration. Hydrogels are biocompatible hydrophilic polymer structures that can imbibe large amounts of water or biological fluids. Hydrogels are one of the upcoming classes of polymer-based systems that embrace numerous biomedical applications. This work is aimed to present a novel method to fabricate alginate-based calcium crosslinked hydrogels by manipulating gelation at high pressure. The cryogels can be obtained after freeze-drying. Cryogels for biomedical applications are of special interest due to large and highly interconnected pores that provide non-constrained mass transfer for cell growth and proliferation. However, to achieve desirable mechanical properties as well as high adsorption capacity, bimodal meso and macroporous materials are greatly desirable.
AccessOpen access
Appears in Collections:3B’s - Publicações em atas de conferências - indexadas no ISI Web of Science

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