Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/30681

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dc.contributor.authorRial-Hermida, Maria Isabelpor
dc.contributor.authorOliveira, Nuno M.por
dc.contributor.authorConcheiro, Angelpor
dc.contributor.authorAlvarez-Lorenzo, Carmenpor
dc.contributor.authorMano, J. F.por
dc.date.accessioned2014-10-31T10:50:52Z-
dc.date.available2014-10-31T10:50:52Z-
dc.date.issued2014-06-
dc.date.submitted2014-07-
dc.identifier.issn1742-7061por
dc.identifier.urihttp://hdl.handle.net/1822/30681-
dc.description.abstractSuperamphiphobic surfaces were evaluated as a tool to prepare spherical particles from polymers and solvents of very diverse nature, under mild conditions and with 100% drug encapsulation yield. Different from bioinspired superhydrophobic surfaces suitable only for aqueous dispersions, the superamphiphobic platforms allowed the formation of spherical droplets when solvents of any polarity were deposited onto them. Spherical poly(d,l-lactide-co-glycolide) (PLGA) particles were synthesized by placing drops of PLGA/ciprofloxacin suspensions in dioxane on a superamphiphobic surface followed by solvent evaporation. The particles prepared covering a wide range of PLGA/ciprofloxacin weight ratios delivered a 20% dose in the first 24h and then sustained the release of the remaining drug for more than 1month. The particles, both freshly prepared and after being 26days in the release medium, showed efficiency against different types of microorganisms. The developed polymer- and solvent-independent approach could be useful for microencapsulation with very high efficiency of active substances of varied nature into size-tunable particles for a wide range of applications in an affordable and cost-effective manner.por
dc.description.sponsorshipThis work was supported by Fundacao para a Ciencia e Tecnologia (FCT) through project PTDC/CTM-BIO/1814/2012, Spanish Ministerio de Economia y Competitividad (SAF 2011-22771; PRI-AIBPT-2011-1211), Xunta de Galicia (CN 2012/045) and FEDER. The authors thank Beatriz Magarinos for help with the microbiological experiments.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.rightsrestrictedAccesspor
dc.subjectBiomaterialspor
dc.subjectMicroencapsulationpor
dc.subjectPolymer particlespor
dc.subjectSuperamphiphobic surfacespor
dc.subjectSuperhydrophobic and biomimetic substratespor
dc.subjectSubstratespor
dc.titleBioinspired superamphiphobic surfaces as a tool for polymer-and solvent-independent preparation of drug-loaded spherical particlespor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1742706114002566#por
dc.commentshttp://www.3bs.uminho.pt/node/18060por
sdum.publicationstatuspublishedpor
oaire.citationStartPage4314por
oaire.citationEndPage4322por
oaire.citationIssue10por
oaire.citationTitleActa Biomaterialiapor
oaire.citationVolume10por
dc.date.updated2014-09-11T16:24:38Z-
dc.identifier.doi10.1016/j.actbio.2014.06.009por
dc.identifier.pmid24937139por
dc.subject.wosScience & Technologypor
sdum.journalActa Biomaterialiapor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals


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