Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/30555

TítuloLipocalin 2 modulates the cellular response to amyloid beta
Autor(es)Mesquita, S. D.
Ferreira, A. C.
Falcão, A. M.
Souza, João Carlos Cruz
Oliveira, Tiago Gil
Correia-Neves, Margarida
Sousa, N.
Marques, F.
Palha, Joana Almeida
EditoraNature Publishing Group
RevistaCell Death and Differentiation
Resumo(s)The production, accumulation and aggregation of amyloid beta (Aß) peptides in Alzheimer's disease (AD) are influenced by different modulators. Among these are iron and iron-related proteins, given their ability to modulate the expression of the amyloid precursor protein and to drive Aß aggregation. Herein, we describe that lipocalin 2 (LCN2), a mammalian acute-phase protein involved in iron homeostasis, is highly produced in response to Aß1-42 by choroid plexus epithelial cells and astrocytes, but not by microglia or neurons. Although Aß1-42 stimulation decreases the dehydrogenase activity and survival of wild-type astrocytes, astrocytes lacking the expression of Lcn2 are not affected. This protection results from a lower expression of the proapoptotic gene Bim and a decreased inflammatory response. Altogether, these findings show that Aß toxicity to astrocytes requires LCN2, which represents a novel mechanism to target when addressing AD.Cell Death and Differentiation advance online publication, 23 May 2014; doi:10.1038/cdd.2014.68.
Versão da editorawww.nature.com
Arbitragem científicayes
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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