Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/30302

TitleMicro/nano replication and 3D assembling techniques for scaffold fabrication
Author(s)Lima, M. J.
Correlo, V. M.
Reis, R. L.
KeywordsScaffolds
Micro/nanofabrication
Hot embossing
Soft lithography
Patterning
Issue dateSep-2014
PublisherElsevier
JournalMaterials science and engineering : C
Abstract(s)The development of tissue engineering field entails the creation of micro/nanoscale features for cellular alignment and biocompatibility improvement. As replication techniques, hot embossing and soft lithography can be used to produce micro/nanoscale features on biodegradable membranes. Subsequently the generation of 3D scaffolds can be done by means of assembling techniques. Using the described techniques, high resolution of features, as small as 5nm, can be achieved. Nevertheless membrane assembling must be fully studied to avoid feature fluctuations and even collapse of the scaffold. The present review focuses on the state-of-the-art in the replication techniques used to create micro/nanoscale features on biodegradable polymers and assembling approaches to construct scaffolds with the aim of exploring existing advances and limitations of the reported methods.
TypeArticle
URIhttp://hdl.handle.net/1822/30302
DOI10.1016/j.msec.2014.05.064
ISSN0928-4931
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S0928493114003476#
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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