Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/30292

TítuloImmobilization of bioactive factor-loaded liposomes on the surface of electrospun nanofibers targeting tissue engineering
Autor(es)Monteiro, Nelson
Martins, Albino
Pires, R. A.
Faria, Susana
Fonseca, Nuno A.
Moreira, João N.
Reis, R. L.
Neves, N. M.
Palavras-chaveDelivery system
Dexamethasone
Liposome
Nanofibers
Stem cell differentiation
DataMai-2014
EditoraThe Royal Society of Chemistry
RevistaBiomaterials Science
CitaçãoMonteiro N., Martins A., Pires R. A., Faria S., Fonseca N. A., Moreira J. N., Reis R. L., Neves N. M. Immobilization of bioactive factor-loaded liposomes on the surface of electrospun nanofibers targeting tissue engineering., Biomaterials Science, Vol. 2, pp. 1195-1209, doi:10.1039/c4bm00069b, 2014
Resumo(s)Electrospun nanofiber meshes (NFM), due to their morphology and fibrous structure, are extensively proposed as biomedical devices, for tissue engineering on scaffolds and also as drug delivery systems. Liposomes are nanoparticles prepared from a biologically derived material (phospholipid), which are already in clinical use as a drug release device. Liposomes may be combined with biomaterial scaffolds to promote a local and sustained delivery of loaded bioactive agents. The main objective of the present study is to evaluate the efficacy of dexamethasone (Dex)-loaded liposomes immobilized on the surface of electrospun polycaprolactone (PCL) NFM for promoting the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs). Thein vitrorelease profile demonstrates a sustained release of Dex over 21 days, after an initial burst release over 12 h. Biological assays show that Dex-loaded liposomes immobilized on the surface of electrospun PCL NFMs do not exhibit any cytotoxic effect, being able to successfully promote the osteogenic differentiation of hBMSCs. We herein validate the concept of using liposomes immobilized on the surface of a nanostructured fibrous system to be used as an advanced cell carrier device with autonomous release of growth/differentiation factors relevant for tissue engineering and regenerative medicine strategies.
Tipoarticle
URIhttp://hdl.handle.net/1822/30292
DOI10.1039/c4bm00069b
Arbitragem científicayes
AcessorestrictedAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals


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