Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/30221

Full metadata record
DC FieldValueLanguage
dc.contributor.authorCustódio, Catarina Almeidapor
dc.contributor.authorReis, R. L.por
dc.contributor.authorMano, J. F.por
dc.date.accessioned2014-09-23T11:08:03Z-
dc.date.available2014-09-23T11:08:03Z-
dc.date.issued2014-01-
dc.date.submitted2014-01-
dc.identifier.issn2192-2640por
dc.identifier.urihttp://hdl.handle.net/1822/30221-
dc.description.abstractEngineered cell instructive microenvironments with the ability to stimulate specific cellular responses is a topic of high interest in the fabrication and development of biomaterials for application in tissue engineering. Cells are inherently sensitive to the in vivo microenvironment that is often designed as the cell “niche”. The cell “niche” comprising the extracellular matrix and adjacent cells, influences not only cell architecture and mechanics, but also cell polarity and function. Extensive research has been performed to establish new tools to fabricate biomimetic advanced materials for tissue engineering that incorporate structural, mechanical and biochemical signals that interact with cells in a controlled manner and to recapitulate the in vivo dynamic microenvironment. Bioactive tunable microenvironments using micro and nanofabrication have been successfully developed and proven to be extremely powerful to control intracellular signaling and cell function. This review is focused in the assortment of biochemical signals that have been explored to fabricate bioactive cell microenvironments and the main technologies and chemical strategies to encode them in engineered biomaterials with biological information.por
dc.description.sponsorshipThe authors thank Fundacao para a Ciencia e Tecnologia for C.A.C.'s PhD grant (SFRH/BD/61390/2009). This work was carried out under the scope of the European Union's Seventh Framework Programme (FP7/2007-2013) under grant agreement no REGPOT-CT2012-316331-POLARIS.por
dc.language.isoengpor
dc.publisherWileypor
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F61390%2F2009/PT-
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/316331/EU-
dc.rightsopenAccesspor
dc.subjectBiomaterialspor
dc.subjectCell microenvironmentspor
dc.subjectFunctional materialspor
dc.subjectTissue engineeringpor
dc.titleEngineering biomolecular microenvironments for cell instructive biomaterialspor
dc.typearticle-
dc.peerreviewedyespor
dc.commentshttp://www.3bs.uminho.pt/node/17864por
sdum.publicationstatuspublishedpor
oaire.citationStartPage797por
oaire.citationEndPage810por
oaire.citationIssue6por
oaire.citationTitleAdvanced Healthcare Materialspor
oaire.citationVolume3por
dc.date.updated2014-09-11T15:43:41Z-
dc.identifier.doi10.1002/adhm.201300603por
dc.identifier.pmid24464880por
dc.subject.wosScience & Technologypor
sdum.journalAdvanced Healthcare Materialspor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
17864-Abstract .pdf189,22 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID