Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/30147

TítuloNanoparticulate bioactive-glass-reinforced gellan-gum hydrogels for bone-tissue engineering
Autor(es)Gantar, Ana
Silva, L. P. da
Oliveira, Joaquim M.
Marques, A. P.
Correlo, V. M.
Novak, S.
Reis, R. L.
Palavras-chaveBioactive glass
Gellan Gum
Scaffold
Composite
Bone-tissue engineering
DataOut-2014
EditoraElsevier
RevistaMaterials Science and Engineering: C
CitaçãoGantar A., da Silva L. P., Oliveira J. M., Marques A. P., Correlo V. M., Novak S., Reis R. L. Nanoparticulate bioactive-glass-reinforced gellan-gum hydrogels for bone-tissue engineering, Materials Science and Engineering C, Vol. 43, pp. 27-36, 2014
Resumo(s)his work presents bioactive-glass-reinforced gellan-gum spongy-like hydrogels (GG-BAG) as novel hydrophilic materials for use as the scaffolding in bone-tissue engineering. The reinforcement with bioactive-glass particles resulted in an improvement to the microstructure and to the mechanical properties of the material. These mechanical properties were found to be dependent on the composition and improved with the amount of bioactive glass; however, values necessary to accommodate biomechanical loading were not achieved in this study. Nevertheless, by incorporating the bioactive-glass particles, the composite material acquired the ability to form an apatite layer when soaked in simulated body fluid. Furthermore, human-adipose-derived stem cells were able to adhere and spread within the gellan-gum, spongy-like hydrogels reinforced with the bioactive glass, and remain viable, which is an important result when considering their use in bone-tissue engineering. Thus, hydrogels based on gellan gum and bioactive glass are promising biomaterials for use either alone or with cells, and with the potential for use in osteogenic differentiation.
Tipoarticle
URIhttp://hdl.handle.net/1822/30147
DOI10.1016/j.msec.2014.06.045
Versão da editorahttp://www.sciencedirect.com/science/article/pii/S0928493114004159
Arbitragem científicayes
AcessorestrictedAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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