Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/30147

TitleNanoparticulate bioactive-glass-reinforced gellan-gum hydrogels for bone-tissue engineering
Author(s)Gantar, Ana
Silva, L. P. da
Oliveira, Joaquim M.
Marques, A. P.
Correlo, V. M.
Novak, S.
Reis, R. L.
KeywordsBioactive glass
Gellan Gum
Scaffold
Composite
Bone-tissue engineering
Issue dateOct-2014
PublisherElsevier
JournalMaterials Science and Engineering: C
CitationGantar A., da Silva L. P., Oliveira J. M., Marques A. P., Correlo V. M., Novak S., Reis R. L. Nanoparticulate bioactive-glass-reinforced gellan-gum hydrogels for bone-tissue engineering, Materials Science and Engineering C, Vol. 43, pp. 27-36, 2014
Abstract(s)his work presents bioactive-glass-reinforced gellan-gum spongy-like hydrogels (GG-BAG) as novel hydrophilic materials for use as the scaffolding in bone-tissue engineering. The reinforcement with bioactive-glass particles resulted in an improvement to the microstructure and to the mechanical properties of the material. These mechanical properties were found to be dependent on the composition and improved with the amount of bioactive glass; however, values necessary to accommodate biomechanical loading were not achieved in this study. Nevertheless, by incorporating the bioactive-glass particles, the composite material acquired the ability to form an apatite layer when soaked in simulated body fluid. Furthermore, human-adipose-derived stem cells were able to adhere and spread within the gellan-gum, spongy-like hydrogels reinforced with the bioactive glass, and remain viable, which is an important result when considering their use in bone-tissue engineering. Thus, hydrogels based on gellan gum and bioactive glass are promising biomaterials for use either alone or with cells, and with the potential for use in osteogenic differentiation.
TypeArticle
URIhttp://hdl.handle.net/1822/30147
DOI10.1016/j.msec.2014.06.045
ISSN0928-4931
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S0928493114004159
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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