Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/29733

TitleVascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors
Author(s)Heinke, Thaís
Espiríto Santo, Kleber Simões do
Longatto Filho, Adhemar
Stávale, João N.
KeywordsGlioma
Neovascularization
Pathologic
Immunohistochemistry
Issue dateJan-2013
JournalActa Cirúrgica Brasileira
Abstract(s)PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention.
TypeArticle
URIhttp://hdl.handle.net/1822/29733
DOI10.1590/S0102-86502013000100008
ISSN0102-8650
1678-2674
Publisher versionhttp://www.scielo.br/scielo.php?script=sci_serial&pid=0102-8650&lng=en&nrm=iso
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
heinke thais_acta cirurg brasil 2013.pdf1,17 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID