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TitleOpportunity for catch-up HPV vaccination in young women after first delivery
Author(s)Rama, Cristina Helena
Villa, Luisa Lina
Paglius, Sonia
Andreoli, Maria Antonieta
Costa, Maria Cecilia
Thomann, Patricia
Alves, Venâncio Avancini Ferreira
Longatto Filho, Adhemar
Eluf Neto, José
Issue dateJul-2010
PublisherBMJ Publishing Group
JournalJournal of Epidemiology & Community Health -
Abstract(s)BACKGROUND: Early age at first delivery has been identified as a risk factor for high-risk HPV-type infection and cervical cancer development. METHODS: A cross-sectional study was carried out in a large public maternity hospital in São Paulo, Brazil. During June 2006 to February 2007, 301 women aged 15-24 years who gave birth to their first child were recruited between 43 and 60 days after delivery. Detection of HPV DNA in cervical specimens was performed using a standardised PCR protocol with PGMY09/11 primers. The association of selected factors with HPV infection was assessed by using a Generalised Linear Model. RESULTS: HPV DNA was detected in 58.5% (95% CI 52.7% to 64.0%) of the enrolled young women. The most common types of HPV found were: HPV16, HPV51, HPV52, HPV58 and HPV71. The overall prevalence of HPV types targeted by the HPV prophylactic vaccines was: HPV 16-12.0%, HPV 18- 2.3% and HPV 6 and 11 4.3%. In the multivariate analysis, only age (inversely, p for trend=0.02) and smoking habits were independently associated with HPV infection. CONCLUSIONS: The findings show that these young primiparous women had high cervical HPV prevalence, suggesting that this is a high-risk group for cervical cancer development. Nevertheless, 17.3% were positive for any of the four HPV types included in HPV vaccines (HPV6, 11, 16 or 18), with 13.3% positive for HPV 16 or 18 and only 1.0% having both vaccine related-oncogenic HPV types. Thus, young primiparous women could benefit from catch-up HPV vaccination programmes.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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