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TitleInfluence of amygdaloid glutamatergic receptors on sensory and emotional pain-related behavior in the neuropathic rat
Author(s)Ansah, Osei B.
Bourbia, Nora
Gonçalves, Leonor
Almeida, Armando
Pertovaara, Antti
Aversive place-conditioning
Descending pain modulation
Emotional pain
Mechanical pain sensibility
Peripheral neuropathy
Issue date2010
JournalBehavioural Brain Research
Abstract(s)The role of amygdaloid glutamatergic receptors (GluRs) in maintenance of the sensory versus emotional component of neuropathic pain was studied by assessing monofilament-induced limb withdrawal response (sensory pain) and aversive place-conditioning behavior (emotional pain) following amygdaloid administration of various glutamatergic compounds in nerve-injured animals. The results indicate that endogenous activation of amygdaloid group I metabotropic GluRs, mGluR(1) and mGluR(5), and the NMDA-R contributes to maintenance of sensory and emotional components of neuropathic pain. The predominant effect by amygdaloid group I mGluRs was facilitation of emotional-like pain behavior.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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