Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/2948

TitleVEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels
Author(s)Longatto Filho, Adhemar
Martins, Albino
Costa, Sandra Maria Araújo da
Schmitt, Fernando C.
KeywordsLymphangiogenesis
Angiogenesis
Vascular endothelial growth factor receptor 3
Breast cancer
Issue date2005
PublisherElsevier
JournalPathology : Research and Practice
Citation"Pathology : Research and Practice" . ISSN 0344-0338. 201:2 (2005) 93-99.
Abstract(s)We examined the immunohistochemical reactivity for vascular endothelial growth factor receptor 3 (VEGFR-3), a protein playing an important role in lymphangiogenesis, in breast cancer. A retrospective series of 77 invasive ductal breast carcinomas was investigated. The relationship between VEGFR-3 expression and clinicopathologic parameters was examined for statistical significance using Pearson’s chi-square ðw2Þ test and Fisher’s exact test (when no5). Threshold for significance was po0:05: Patient age ranged from 31 to 77 years (mean: 55 years). The VEGFR-3 immunoreactivity was as follows: 5 cases were negative (6.5%), 35+(45.4%), 27++ (35.1%), and 10+++ (13.0%). Reactions were positive for both lymphatic and blood vessels in several cases. VEGFR-3-positive reactions were more frequent in the tumor periphery than within the tumor. Immunoreactivity was also observed in myoepithelial cells surrounding both normal ducts and ducts with ductal carcinoma in situ. Statistical analysis of VEGFR-3 reactions was not significantly related to node status, microvessel density, and tumor grade. Ploidy showed a tendency towards significance (p=0.063); however, owing to the limited number of cases, statistical significance was not reached. VEGFR-3 lacks lymphatic vessel specificity and is also expressed in blood vessels, myoepithelial cells, and neoplastic cells.
TypeArticle
URIhttp://hdl.handle.net/1822/2948
DOI10.1016/j.prp.2004.11.008
ISSN0344-0338
Publisher versionhttp://www.elsevier.com/wps/find/journaldescription.cws_home/701791/description#description
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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