Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/29335

TítuloCaloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H₂O₂ and superoxide dismutase activity
Autor(es)Mesquita, Ana Maria Macedo
Weinberger, Martin
Silva, Alexandra
Marques, Belém Sampaio
Almeida, Bruno
Leão, Cecília
Costa, Vitor
Rodrigues, Fernando José dos Santos
Burhans, William C.
Ludovico, Paula
Palavras-chaveAging
Hydrogen peroxide
Hormesis
Antioxidant enzymes
Oxidative
Data2010
EditoraNational Center for Biotechnology Information
RevistaProceedings of the National Academy of Sciences
Resumo(s)The free radical theory of aging posits oxidative damage to macromolecules as a primary determinant of lifespan. Recent studies challenge this theory by demonstrating that in some cases, longevity is enhanced by inactivation of oxidative stress defenses or is correlated with increased, rather than decreased reactive oxygen species and oxidative damage. Here we show that, in Saccharomyces cerevisiae, caloric restriction or inactivation of catalases extends chronological lifespan by inducing elevated levels of the reactive oxygen species hydrogen peroxide, which activate superoxide dismutases that inhibit the accumulation of superoxide anions. Increased hydrogen peroxide in catalase-deficient cells extends chronological lifespan despite parallel increases in oxidative damage. These findings establish a role for hormesis effects of hydrogen peroxide in promoting longevity that have broad implications for understanding aging and age-related diseases.
Tipoarticle
URIhttp://hdl.handle.net/1822/29335
DOI10.1073/pnas.1004432107
ISSN0027-8424
Versão da editorahttp://www.pnas.org/content/107/34/15123
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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