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TitleMicrotubule-associated protein tau is essential for long-term depression in the hippocampus
Author(s)Kimura, Tetsuya
Whitcomb, Daniel J.
Jo, Jihoon
Regan, Philip
Piers, Thomas
Heo, Seonghoo
Brown, Christopher
Hashikawa, Tsutomu
Murayama, Miyuki
Seok, Heon
Sotiropoulos, I.
Kim, Eunjoon
Collingridge, Graham L.
Takashima, Akihiko
Cho, Kwangwook
KeywordsAlzheimer's disease
synaptic plasticity
long-term depression
Issue date2014
PublisherRoyal Society
JournalPhilosophical Transactions of the Royal Society B : Biological Sciences
Abstract(s)The microtubule-associated protein tau is a principal component of neurofibrillary tangles, and has been identified as a key molecule in Alzheimer's disease and other tauopathies. However, it is unknown how a protein that is primarily located in axons is involved in a disease that is believed to have a synaptic origin. To investigate a possible synaptic function of tau, we studied synaptic plasticity in the hippocampus and found a selective deficit in long-term depression (LTD) in tau knockout mice in vivo and in vitro, an effect that was replicated by RNAi knockdown of tau in vitro. We found that the induction of LTD is associated with the glycogen synthase kinase-3-mediated phosphorylation of tau. These observations demonstrate that tau has a critical physiological function in LTD.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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