Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/28432

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dc.contributor.authorGonçalves, Bruno-
dc.contributor.authorFontainhas, Vasco-
dc.contributor.authorCaetano, Ana Célia-
dc.contributor.authorFerreira, Aníbal-
dc.contributor.authorGonçalves, Raquel-
dc.contributor.authorBastos, Pedro-
dc.contributor.authorRolanda, Carla-
dc.date.accessioned2014-03-19T14:35:12Z-
dc.date.available2014-03-19T14:35:12Z-
dc.date.issued2013-
dc.date.submitted2013-
dc.identifier.issn1130-0108por
dc.identifier.urihttp://hdl.handle.net/1822/28432-
dc.description.abstractObjective: malignant colorectal polyp, defined by submucosally invasive adenocarcinoma, is the earliest form of clinically relevant colorectal cancer (CRC). After endoscopic resection additional surgery may be necessary, although decision criteria remain debatable. The objective of this study was to assess oncologic outcomes in terms of locoregional disease and to identify areas of improvement that may facilitate patients´ management.Methods: retrospective study of 40 patients with T1 CRC endoscopically resected between 2007 and 2012. Clinicopathological features were assessed and correlated with residual disease (RD), defined as presence of adenocarcinoma in intestinal wall and/ or lymph nodes.Results: thirty-one patients underwent surgery while 9 were followed-up. After surgery, RD was confirmed in 15 (48.4 %) patients: 8 (53.3 %) wall disease, 5 (33 %) nodal metastasis, and 2 (13.3 %) with both. No recurrence was detected in the follow-up group. The characteristics of the lesions that were associated with DR were sessile configuration (p = 0.03), the degree of differentiation G3 (p = 0.01) and intercepted/indeterminate margins (p = 0.01). Twenty-two patients were operated because of inadequate evaluation, mainly due to piecemeal resection, and half of them were disease free. Postoperative complications were found in 9 (30 %) patients, mainly anastomotic leakage that was associated with rectum anterior resection (p = 0.03).Conclusions: surgery should be considered in the presence of any risk factor for residual disease, while follow-up can be offered in low risk settings. Was also demonstrated a clear need for technical improvement in endoscopic resection and pathology evaluation in order to prevent unnecessary surgeries.por
dc.language.isoengpor
dc.publisherArán Ediciones, S.L.por
dc.rightsopenAccesspor
dc.subjectMalignant polyppor
dc.subjectPostoperative complicationspor
dc.subjectResidualpor
dc.subjectRisk factorspor
dc.subjectSubmucosal invasionpor
dc.subjectResidual diseasepor
dc.titleOncological outcomes after endoscopic removal of malignant colorectal polypspor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://scielo.isciii.es/scielo.php/script_sci_serial/pid_1130-0108/lng_es/nr/lng_enpor
sdum.publicationstatuspublishedpor
oaire.citationStartPage454por
oaire.citationEndPage461por
oaire.citationIssue8por
oaire.citationTitleRevista Española de Enfermedades Digestivaspor
oaire.citationVolume105por
dc.date.updated2014-03-06T17:35:54Z-
dc.identifier.doi10.4321/S1130-01082013000800003por
dc.identifier.pmid24274442por
dc.subject.wosScience & Technologypor
sdum.journalRevista Española de Enfermedades Digestivaspor
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