Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/2823

TitleDesmoplastic small round cell tumour : cytological and immunocytochemical features
Author(s)Granja, Nara M.
Begnami, Maria D.
Bortolan, Jeni
Longatto Filho, Adhemar
Schmitt, Fernando C.
Issue date18-Mar-2005
PublisherBioMed Central
JournalCytojournal
CitationGRANJA, Nara M. [et al.] - Desmoplastic small round cell tumour : cytological and immunocytochemical features. "CytoJournal" [Em linha]. 2 (2005). [Consult. 7 Set. 2005]. Disponível em: http://www.cytojournal.com/content/2/1/6.
Abstract(s)Background: Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive neoplasm. The cytological diagnosis of these tumors can be difficult because they show morphological features quite similar to other small round blue cells tumors. We described four cases of DSRCT with cytological sampling: one obtained by fine needle aspiration biopsy (FNAB) and three from serous effusions. The corresponding immunocytochemical panel was also reviewed. Methods: Papanicolaou stained samples from FNAB and effusions were morphologically described. Immunoreaction with WT1 antibody was performed in all cytological samples. An immunohistochemical panel including the following antibodies was performed in the corresponding biopsies: 34BE12, AE1/AE3, Chromogranin A, CK20, CK7, CK8, Desmin, EMA, NSE, Vimentin and WT1. Results: The smears showed high cellularity with minor size alteration. Nuclei were round to oval, some of them with inconspicuous nucleoli. Tumor cells are clustered, showing rosette-like feature. Tumor cells in effusions and FNA were positive to WT1 in 3 of 4 cytology specimens (2 out 3 effusions and one FNA). Immunohistochemical reactions for vimentin, NSE, AE1/AE3 and WT1 were positive in all cases in tissue sections. Conclusion: The use of an adjunct immunocytochemical panel coupled with the cytomorphological characteristics allows the diagnosis of DSRCT in cytological specimens.
TypeArticle
URIhttp://hdl.handle.net/1822/2823
DOI10.1186/1742-6413-2-6
ISSN1742-6413
Publisher versionhttp://www.biomedcentral.com/
http://www.cytojournal.com/content/2/1/6
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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