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TitleLiposome and protein based stealth nanoparticles
Author(s)Nogueira, Eugénia Sofia Costa
Loureiro, Ana
Nogueira, Patrícia
Freitas, Jaime
Almeida, Catarina R.
Harmark, Johan
Hebert, Hans
Moreira, Alexandra
Carmo, Alexandre M.
Preto, Ana
Gomes, Andreia
Paulo, Artur Cavaco
Issue date2013
PublisherRoyal Society of Chemistry
JournalFaraday Discussions
Abstract(s)Liposomes and protein based nanoparticles were tuned with different polymers and glycolipids to improve stealth and thus decrease their clearance by macrophages. Liposomes were coated with polyethylene glycol (PEG) and brain-tissue-derived monosialoganglioside (GM1). Bovine serum albumin (BSA) nanoparticles were produced incorporating a PEGylated surfactant (PEG-surfactant). All obtained nanoparticles were monodisperse, with sizes ranging from 80 to 120 nm, with a zetapotential close to zero. The presented stealth strategies lead to a decrease of internalization levels by macrophages. These surface modified nanoparticles could be used for production of new drug delivery nanosystems for systemic administration (e.g. intravenous application).
AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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