Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/27355
Título: | Amide conjugates of the DO3A-N-(alpha-amino)propionate ligand: leads for stable, high relaxivity contrast agents for MRI? |
Autor(es): | Ferreira, Miguel Filipe Moreira Marques Martins, André F. Martins, Catarina I. O. Ferreira, Paula M. T. Tóth, Éva Rodrigues, Tiago B. Calle, Daniel Cerdan, Sebastian López-Larrubia, Pilar Martins, José A. Geraldes, Carlos F. G. C. |
Palavras-chave: | DO3A-N-(alfa-amido)propionate chelators Gd[DO3A-N-(alfa-benzoylamido)propionate] chelate Fast water exchange pH stability Safety in vivo MRI DO3A-N-(alpha-amido)propionate chelators Gd[DO3A-N-(alpha-benzoylamido)propionate] chelate |
Data: | 2013 |
Editora: | Wiley |
Revista: | Contrast media and molecular imaging |
Resumo(s): | A novel synthetic methodology for preparing amide conjugates of the DO3A-N-(alfa-amino)propionate chelator is described, using the synthesis of the DO3A-N-(alfa-benzoylamido)propionate chelator as an illustrative example. The model Gd(DO3A-N-(alfa-benzoylamido)propionate) chelate displays accelerated water exchange, stability in a wide pH range and inertness towards transmetallation by Zn2+. The Gd(DO3A-N-(alafa-benzoylamido)propionate) complex is mainly excreted via the kidneys, producing a significant increase of the kidney medulla/cortex enhancement ratio in MR images of Wistar rats, reflecting probably its increased hydrophobicity compared to Gd(DTPA). The results presented suggest that Gd(DO3A-N-(alfa-amido)propionate) chelates can be valuable leads for preparing potentially safe high relaxivity MRI contrast agents. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/27355 |
DOI: | 10.1002/cmmi.1492 |
ISSN: | 1555-4317 |
Versão da editora: | https://onlinelibrary.wiley.com/doi/full/10.1002/cmmi.1492 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | CDQuim - Artigos (Papers) |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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DO3A-N-(alfa-amido)propionate_leads_RepositoriUM.pdf | Manuscript and Supporting Information | 921,35 kB | Adobe PDF | Ver/Abrir |