Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/27355

TitleAmide conjugates of the DO3A-N-(alpha-amino)propionate ligand: leads for stable, high relaxivity contrast agents for MRI?
Author(s)Ferreira, Miguel Filipe Moreira Marques
Martins, André F.
Martins, Catarina I. O.
Ferreira, Paula M. T.
Tóth, Éva
Rodrigues, Tiago B.
Calle, Daniel
Cerdan, Sebastian
López-Larrubia, Pilar
Martins, José A.
Geraldes, Carlos F. G. C.
KeywordsDO3A-N-(alfa-amido)propionate chelators
Gd[DO3A-N-(alfa-benzoylamido)propionate] chelate
Fast water exchange
pH stability
Safety
in vivo MRI
DO3A-N-(alpha-amido)propionate chelators
Gd[DO3A-N-(alpha-benzoylamido)propionate] chelate
Issue date2013
PublisherWiley
JournalContrast media and molecular imaging
Abstract(s)A novel synthetic methodology for preparing amide conjugates of the DO3A-N-(alfa-amino)propionate chelator is described, using the synthesis of the DO3A-N-(alfa-benzoylamido)propionate chelator as an illustrative example. The model Gd(DO3A-N-(alfa-benzoylamido)propionate) chelate displays accelerated water exchange, stability in a wide pH range and inertness towards transmetallation by Zn2+. The Gd(DO3A-N-(alafa-benzoylamido)propionate) complex is mainly excreted via the kidneys, producing a significant increase of the kidney medulla/cortex enhancement ratio in MR images of Wistar rats, reflecting probably its increased hydrophobicity compared to Gd(DTPA). The results presented suggest that Gd(DO3A-N-(alfa-amido)propionate) chelates can be valuable leads for preparing potentially safe high relaxivity MRI contrast agents.
TypeArticle
URIhttp://hdl.handle.net/1822/27355
DOI10.1002/cmmi.1492
ISSN1555-4317
Publisher versionhttps://onlinelibrary.wiley.com/doi/full/10.1002/cmmi.1492
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CDQuim - Artigos (Papers)

Files in This Item:
File Description SizeFormat 
DO3A-N-(alfa-amido)propionate_leads_RepositoriUM.pdfManuscript and Supporting Information921,35 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID