Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/272
Título: | Porous starch-based drug delivery systems processed by a microwave route |
Autor(es): | Malafaya, P. B. Elvira, C. Gallardo, A. San Román, J. Reis, R. L. |
Palavras-chave: | Starch Carriers Drug Delivery Systems Biodegradable Porous Systems |
Data: | 2001 |
Editora: | VSP |
Revista: | Journal of Biomaterials Science. Polymer Edition |
Citação: | "Journal of Biomaterials Science: Polymer Edition". 12:11 (2001) 1227-1241. |
Resumo(s): | A new simple processing route to produce starch-based porous materials was developed based on a microwave baking methodology. This innovative processing route was used to obtain non-loaded controls and loaded drug delivery carriers, incorporating a non-steroid anti-inflammatory agent. This bioactive agent was selected as model drug with expectations that the developed methodology might be used for other drugs and growth factors. The prepared systems were characterized by 1H and 13C NMR spectroscopy which allow the study of the interactions between the starch-based materials and the processing components, i.e. the blowing agents. The porosity of the prepared materials was estimated by measuring their apparent density and studied by comparing drug-loaded and non-loaded carriers. The behaviour of the porous structures, while immersed in aqueous media, was studied in terms of swelling and degradation, being intimately related to their porosity. Finally, in vitro drug release studies were performed showing a clear burst effect, followed by a slow controlled release of the drug over several days (up to 10 days). |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/272 |
DOI: | 10.1163/156856201753395761 |
ISSN: | 0920-5063 |
e-ISSN: | 1227-1241 |
Arbitragem científica: | yes |
Acesso: | Acesso restrito UMinho |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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PBM_microwave_JBSPE2001.pdf Acesso restrito! | 2,34 MB | Adobe PDF | Ver/Abrir |