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TitleThiolated chitosan/glycosaminoglycans multilayered films : QCM-D study on the films formation and their biological properties
Author(s)Francesko, Antonio
Díaz-Blanco, Carlos
Lisboa, P.
Costa, Diana Soares da
Pashkuleva, I.
Reis, R. L.
Tzanov, Tzanko
Layer-by-layer assembly
Issue dateMar-2012
PublisherAmerican Chemical Society
JournalAbstracts of Papers of the American Chemical Society
Abstract(s)Layer-by-layer technique is widely used to produce polyelectrolyte multilayered films for material surface functionalization. The technique simplicity coupled with the biological potential of biopolymers, e.g. polysaccharides, make such assemblies a suitable choice for many biomedical applications. In this study the formation of the films comprising of thiolated chitosan and glycosaminoglycans (GAGs) by alternate deposition was assessed in situ using QCM-D. Thiolated chitosan was used under the hypothesis of disulfide formation between its molecules to increase stability and/or stiffness of the films. The effects of the chitosan modification degree and GAGs molecular weight on the film thickness were investigated. All experimental groups showed exponential film growth, while the thickness increased with the chitosan thiolation degree and molecular weight of GAGs. Cellular behavior on the assemblies was found to be tunable by the appropriate selection of the terminate layer. Antimicrobial activity and protein adsorption on the new constructs are also commented.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Resumos em livros de atas de conferências - indexados no ISI Web of Science

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