Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/27056

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dc.contributor.authorRodríguez-Valencia, Cosme-
dc.contributor.authorPereiro, Iago-
dc.contributor.authorPirraco, Rogério-
dc.contributor.authorLopéz-Álvarez, M.-
dc.contributor.authorSerra, J.-
dc.contributor.authorGonzález, P.-
dc.contributor.authorMarques, A. P.-
dc.contributor.authorReis, R. L.-
dc.date.accessioned2013-12-16T17:31:02Z-
dc.date.available2013-12-16T17:31:02Z-
dc.date.issued2014-
dc.date.submitted2013-11-
dc.identifier.issn0885-3282por
dc.identifier.urihttp://hdl.handle.net/1822/27056-
dc.description.abstractThe search for apatitic calcium phosphate coatings to improve implants osteointegration is, nowadays, preferentially focused in the obtaining of compositions closer to that of the inorganic phase of bone. Silicon and strontium are both present in trace concentrations in natural bone and have been demonstrated, by separate, to significantly improve osteoblastic response on calcium phosphate bioceramics. This work aims the controlled and simultaneous multidoping of carbonated calcium phosphate coatings with both elements, Si and Sr, by pulsed laser deposition technique and the biological response of human mesenchymal stem cells to them. A complete physicochemical characterization has been also performed to analyze the coatings and significant positive effect was obtained at the osteogenic differentiation of cells, confirming the enormous potential of this multi-doping coating approach.por
dc.description.sponsorshipTechnical staff of CACTI (University of Vigo) is gratefully acknowledged. This work was partially supported by the UE-POCTEP 0330IBEROMARE1P project, UE-INTERREG 2011-1/164MARMED and Ministerio de Ciencia e Innovacion (Project MAT2010-18281). M Lopez-Alvarez thanks funding support from FP7/REGPOT-2012-2013.1 (no 316265, BIOCAPS).por
dc.language.isoengpor
dc.publisherSAGEpor
dc.rightsopenAccesspor
dc.subjectCalcium phosphatepor
dc.subjectHuman bone marrow-derived mesenchymal stem cells differentiationpor
dc.subjectMulti-doped coatingspor
dc.subjectPulsed laser depositionpor
dc.subjectSiliconpor
dc.subjectStrontiumpor
dc.titleHuman mesenchymal stem cells response to multi-doped silicon-strontium calcium phosphate coatingspor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://jba.sagepub.com/content/early/2013/10/25/0885328213510056.abstractpor
dc.commentshttp://www.3bs.uminho.pt/node/17813por
sdum.publicationstatuspublishedpor
oaire.citationStartPage1por
oaire.citationEndPage11por
oaire.citationIssue9por
oaire.citationTitleJournal of Biomaterials Applicationspor
oaire.citationVolume28por
dc.date.updated2013-11-07T11:29:32Z-
dc.identifier.doi10.1177/0885328213510056-
dc.identifier.pmid24163332por
dc.subject.wosScience & Technologypor
sdum.journalJournal of Biomaterials Applicationspor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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