Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/27055

TítuloSilk Fibroin/Nano-CaP Bilayered scaffolds for osteochondral tissue engineering
Autor(es)Yan, Leping
Oliveira, Joaquim M.
Oliveira, A. L.
Reis, R. L.
Palavras-chaveBilayered scaffold
Nano calcium phosphate
Osteochondral tissue engineering
Silk fibroin
DataJan-2014
EditoraTrans Tech Publications, Switzerland
RevistaKey Engineering Materials
Resumo(s)In this study, bilayered silk and silk/nano-CaP scaffolds were developed for osteochondral (OC) tissue engineering. Aqueous silk solution (16 wt.%) was used for preparation of the cartilage-like layer and, for generation of the silk/nano-CaP suspension and the bottom layer (CaP/Silk: 16 wt.%). The scaffolds were formed by using salt-leaching/lyophilization approach. The scanning electron microscopy revealed that the both layers presented porous structure and integrated well. Micro-computed tomography images confirmed that the CaP phase was only retained in the silk/nano-CaP layer. The hydration degree and mechanical properties of the bilayered scaffold were comparable to the ones of each single layer. The apatite crystal formation was limited to the silk/nano-CaP layer, when soaking the scaffold in a simulated body fluid solution, which is a must for the application of the developed scaffolds in OC tissue engineering
Tipoarticle
URIhttp://hdl.handle.net/1822/27055
ISSN1662-9795
Versão da editorahttp://www.ttp.net/978-3-03785-899-8.html
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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