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TitleSilk Fibroin/Nano-CaP Bilayered scaffolds for osteochondral tissue engineering
Author(s)Yan, Leping
Oliveira, Joaquim M.
Oliveira, A. L.
Reis, R. L.
KeywordsBilayered scaffold
Nano calcium phosphate
Osteochondral tissue engineering
Silk fibroin
Issue dateJan-2014
PublisherTrans Tech Publications
JournalKey Engineering Materials
Abstract(s)In this study, bilayered silk and silk/nano-CaP scaffolds were developed for osteochondral (OC) tissue engineering. Aqueous silk solution (16 wt.%) was used for preparation of the cartilage-like layer and, for generation of the silk/nano-CaP suspension and the bottom layer (CaP/Silk: 16 wt.%). The scaffolds were formed by using salt-leaching/lyophilization approach. The scanning electron microscopy revealed that the both layers presented porous structure and integrated well. Micro-computed tomography images confirmed that the CaP phase was only retained in the silk/nano-CaP layer. The hydration degree and mechanical properties of the bilayered scaffold were comparable to the ones of each single layer. The apatite crystal formation was limited to the silk/nano-CaP layer, when soaking the scaffold in a simulated body fluid solution, which is a must for the application of the developed scaffolds in OC tissue engineering
TypeConference paper
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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