Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/26949

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dc.contributor.authorAlmeida, Hugo Leite-
dc.contributor.authorMelo, António-
dc.contributor.authorPêgo, José M.-
dc.contributor.authorBernardo, Sara-
dc.contributor.authorMilhazes, Nuno-
dc.contributor.authorBorges, Fernanda-
dc.contributor.authorSousa, Nuno-
dc.contributor.authorAlmeida, Armando-
dc.contributor.authorCerqueira, João-
dc.date.accessioned2013-12-12T14:52:48Z-
dc.date.available2013-12-12T14:52:48Z-
dc.date.issued2013-
dc.identifier.issn1662-5153por
dc.identifier.urihttp://hdl.handle.net/1822/26949-
dc.description.abstractTesting impulsive behavior in rodents is challenging and labor-intensive. We developed a new behavioral paradigm-the Variable Delay-to-Signal (VDS) test-that provides rapid and simultaneous assessment of response and decision impulsivity in rodents. Presentation of a light at variable delays signals the permission for action (nose poke) contingent with a reward. 2 blocks of 25 trials at 3 s delay flank a block of 70 trials in which light is presented with randomly selected 6 or 12 s delays. Exposure to such large delays boosts the rate of premature responses when the delay drops to 3 s in the final block, an effect that is blunted by an acute methamphetamine challenge and that correlates with the delay-discounting (DD) paradigm (choice impulsivity). Finally, as expected, treatment with the NMDA antagonist MK-801 caused a generalized response increase in all VDS blocks. The pharmacological validation, particularly with methamphetamine which has a well established dual effect on response and decision impulsivity, and the correlations between the impulsive behavior in the DD and VDS paradigms, suggests that the later is able to provide, in a single session, a multi-dimensional assessment of impulsive behavior.por
dc.description.sponsorshipThe work wa ssupported by a fellowship “SFRH/BPD/80118/2011” funded by FCT—Portuguese Foundation for Science and Technology and by FEDER funds through Operational program for competitivity factors—COMPETE and by national funds through FCT—Foundation for Science and Technology to projects PTDC/SAU-NEU/108557/2008 and PTDC/SAUNSC/111814/2009.-
dc.language.isoengpor
dc.publisherFrontiers Mediapor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/108557/PT-
dc.relationinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/111814/PT-
dc.relationinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F80118%2F2011/PT-
dc.rightsopenAccesspor
dc.subjectRodent behaviorpor
dc.subjectDecision impulsivitypor
dc.subjectResponse impulsivitypor
dc.subjectDelay-discountingpor
dc.subject5-csrttpor
dc.subjectMethamphetaminepor
dc.subjectMK-801por
dc.titleVariable delay-to-signal: a fast paradigm for assessment of aspects of impulsivity in ratspor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://www.frontiersin.org/por
sdum.publicationstatuspublishedpor
oaire.citationStartPage1por
oaire.citationEndPage9por
oaire.citationIssue154por
oaire.citationTitleFrontiers in Behavioral Neurosciencepor
oaire.citationVolume7por
dc.date.updated2013-11-04T11:51:32Z-
dc.identifier.doi10.3389/fnbeh.2013.00154-
dc.subject.wosScience & Technologypor
sdum.journalFrontiers in Behavioral Neurosciencepor
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