Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/26949

TitleVariable delay-to-signal: a fast paradigm for assessment of aspects of impulsivity in rats
Author(s)Almeida, Hugo Leite
Melo, António
Pêgo, José M.
Bernardo, Sara
Milhazes, Nuno
Borges, Fernanda
Sousa, Nuno
Almeida, Armando
Cerqueira, João
KeywordsRodent behavior
Decision impulsivity
Response impulsivity
Delay-discounting
5-csrtt
Methamphetamine
MK-801
Issue date2013
PublisherFrontiers Media
JournalFrontiers in Behavioral Neuroscience
Abstract(s)Testing impulsive behavior in rodents is challenging and labor-intensive. We developed a new behavioral paradigm-the Variable Delay-to-Signal (VDS) test-that provides rapid and simultaneous assessment of response and decision impulsivity in rodents. Presentation of a light at variable delays signals the permission for action (nose poke) contingent with a reward. 2 blocks of 25 trials at 3 s delay flank a block of 70 trials in which light is presented with randomly selected 6 or 12 s delays. Exposure to such large delays boosts the rate of premature responses when the delay drops to 3 s in the final block, an effect that is blunted by an acute methamphetamine challenge and that correlates with the delay-discounting (DD) paradigm (choice impulsivity). Finally, as expected, treatment with the NMDA antagonist MK-801 caused a generalized response increase in all VDS blocks. The pharmacological validation, particularly with methamphetamine which has a well established dual effect on response and decision impulsivity, and the correlations between the impulsive behavior in the DD and VDS paradigms, suggests that the later is able to provide, in a single session, a multi-dimensional assessment of impulsive behavior.
TypeArticle
URIhttp://hdl.handle.net/1822/26949
DOI10.3389/fnbeh.2013.00154
ISSN1662-5153
Publisher versionhttp://www.frontiersin.org/
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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