Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/26838

TitleTissue engineering strategies applied in the regeneration of the human intervertebral disc
Author(s)Correia, Joana Correia
Correia, Sandra I.
Oliveira, Joaquim M.
Reis, R. L.
KeywordsDegeneration
Intervertebral disc
Regeneration
Spinal disorder
Spinal surgery
Tissue engineering
Intervertebral disk
Issue dateJul-2013
PublisherElsevier
JournalBiotechnology Advances
Abstract(s)Low back pain (LBP) is one of the most common painful conditions that lead to work absenteeism, medical visits, and hospitalization. The majority of cases showing signs of LBP are due to age-related degenerative changes in the intervertebral disc (IVD), which are, in fact, associated with multiple spine pathologies. Traditional and more conservative procedures/clinical approaches only treat the symptoms of disease and not the underlying pathology, thus limiting their longterm efficiency. In the last few years, research and development of new approaches aiming to substitute the nucleus pulposus and annulus fibrosus tissue and stimulate its regeneration has been conducted. Regeneration of the damaged IVD using tissue engineering strategies appears particularly promising in pre-clinical studies. Meanwhile, surgical techniques must be adapted to this new approach in order to be as minimally invasive as possible, reducing recovering time and side effects associated to traditional surgeries. In this review, the current knowledge on IVD, its associated pathologies and current surgical procedures are summarized. Furthermore, it also provides a succinct and up-to-date overview on regenerative medicine research, especially on the newest tissue engineering strategies for IVD regeneration
TypeArticle
URIhttp://hdl.handle.net/1822/26838
DOI10.1016/j.biotechadv.2013.07.010
ISSN0734-9750
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S0734975013001249
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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