Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/26294

TitleAn integrated framework for strain optimization
Author(s)Maia, Paulo
Rocha, I.
Rocha, Miguel
Issue date2013
PublisherIEEE
Abstract(s)The identification of genetic modifications leading to mutant strains able to overproduce compounds of industrial interest is a challenging task in Metabolic Engineering (ME). Several methods have been proposed but, to some extent, none of them is suitable for all the specificities of each particular strain optimization problem. This work proposes an integrated framework that allows its users to configure and fine tune all the various steps involved in a strain optimization strategy, including the loading of models in distinct formats, the definition of a suitable phenotype simulation method and the choice and configuration of the strain optimization engine. Moreover, it is designed to suit the needs of users skilled at programming, as well as less advanced users. The framework includes a GUI implemented as the strain optimization plug-in for the OptFlux workbench (version 3), a reference platform for ME (http://www.optflux.org). All the code is distributed under the GPLv3 licence and it is fully available (http://sourceforge.net/projects/optflux/).
TypeConference paper
URIhttp://hdl.handle.net/1822/26294
ISBN978-1-4799-0453-2
DOI10.1109/CEC.2013.6557571
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Artigos em Livros de Atas / Papers in Proceedings

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