Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/25932

TitlePotential of human γD-crystallin for hair damage repair : insights into the mechanical properties and biocompatibility
Author(s)Ribeiro, Artur J.
Matamá, Maria Teresa
Cruz, Célia F.
Gomes, A. C.
Paulo, Artur Cavaco
KeywordsGreek key motif
Hair treatment
Human crystallin
Mechanical properties improvement
Over bleached hair
Issue date2013
PublisherWiley
JournalInternational Journal of Cosmetic Science
Abstract(s)The objective of this work was to develop a new strategy to physically ‘repair’ chemically damaged hair. Hence the human eye γD-crystallin, a protein from the superfamily characterized structurally by the Greek key motif, was studied. The human γD-crystallin was chosen based on the ability of proteins belonging to this superfamily to be involved in the coating of specific structures. Two crystallins were used on the study, the wild type (Protein Data Bank ID: 1HK0) and the mutant protein. The mutant form was intended to induce a strong and quick protein polymerization as well to have new possible points of anchorage to hair.
L'objectif de ce travail était de développer une nouvelle stratégie pour physiquement “réparer” les cheveux chimiquement endommagés. La protéine humaine γD-cristalline, une protéine de la superfamille caractérisée structurellement par le motif clé grecque, a été étudiée. Le γD-cristallin humain a été choisi en fonction de la capacité des protéines appartenant à cette superfamille d'être impliquées dans le revêtement des structures spécifiques. Deux cristallins ont été utilisés dans l'étude, le type sauvage (Protein Data Bank ID: 1HK0) et la protéine mutante. La forme mutante était destinée à induire une polymérisation de la protéine, forte et rapide ainsi d'avoir de nouveaux points d'ancrage possibles aux cheveux.
TypeArticle
URIhttp://hdl.handle.net/1822/25932
DOI10.1111/ics.12065
ISSN1468-2494
Publisher versionhttp://dx.doi.org/10.1111/ics.12065
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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