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TitleControlled release strategies for bone, cartilage, and osteochondral engineering: part I: recapitulation of native tissue healing and variables for the design of delivery systems
Author(s)Santo, Vitor E.
Gomes, Manuela E.
Mano, J. F.
Reis, R. L.
KeywordsBone cartilage
Drug delivery
Tissue engineering and regenerative medicine
Issue dateFeb-2013
PublisherMary Ann Liebert Inc.
JournalTissue Engineering: Part B
CitationSanto V. E., Gomes M. E., Mano J. F., Reis R. L. Controlled Release Strategies for Bone, Cartilage, and Osteochondral Engineering—Part I: Recapitulation of Native Tissue Healing and Variables for the Design of Delivery Systems, TISSUE ENGINEERING: Part B, Vol. 19, Issue 4, doi:10.1089/ten.teb.2012.0138, 2013
Abstract(s)The potential of growth factors to stimulate tissue healing through the enhancement of cell proliferation, migration, and differentiation is undeniable. However, critical parameters on the design of adequate carriers, such as uncontrolled spatiotemporal presence of bioactive factors, inadequate release profiles, and supraphysiological dosages of growth factors, have impaired the translation of these systems onto clinical practice. This review describes the healing cascades for bone, cartilage, and osteochondral interface, highlighting the role of specific growth factors for triggering the reactions leading to tissue regeneration. Critical criteria on the design of carriersfor controlled release of bioactive factors are also reported, focusing on the need to provide a spatiotemporal control over the delivery and presentation of these molecules.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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