Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/25653

TítuloControlled release strategies for bone, cartilage, and osteochondral engineering : part I : recapitulation of native tissue healing and variables for the design of delivery systems
Autor(es)Santo, Vitor E.
Gomes, Manuela E.
Mano, J. F.
Reis, R. L.
Palavras-chaveBone cartilage
Drug delivery
Osteochondral
Tissue engineering and regenerative medicine
DataFev-2013
EditoraMary Ann Liebert, Inc.
RevistaTISSUE ENGINEERING: Part B
CitaçãoSanto V. E., Gomes M. E., Mano J. F., Reis R. L. Controlled Release Strategies for Bone, Cartilage, and Osteochondral Engineering—Part I: Recapitulation of Native Tissue Healing and Variables for the Design of Delivery Systems, TISSUE ENGINEERING: Part B, Vol. 19, Issue 4, doi:10.1089/ten.teb.2012.0138, 2013
Resumo(s)The potential of growth factors to stimulate tissue healing through the enhancement of cell proliferation, migration, and differentiation is undeniable. However, critical parameters on the design of adequate carriers, such as uncontrolled spatiotemporal presence of bioactive factors, inadequate release profiles, and supraphysiological dosages of growth factors, have impaired the translation of these systems onto clinical practice. This review describes the healing cascades for bone, cartilage, and osteochondral interface, highlighting the role of specific growth factors for triggering the reactions leading to tissue regeneration. Critical criteria on the design of carriersfor controlled release of bioactive factors are also reported, focusing on the need to provide a spatiotemporal control over the delivery and presentation of these molecules.
Tipoarticle
URIhttp://hdl.handle.net/1822/25653
DOI10.1089/ten.teb.2012.0138
Versão da editorahttp://online.liebertpub.com/doi/abs/10.1089/ten.teb.2012.0138
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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