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TitleHormonal contraceptives and the length of their use are not independent risk factors for high-risk HPV infections or high-grade CIN
Author(s)Longatto Filho, Adhemar
Hammes, L. Serpa
Sarian, L.
Roteli-Martins, C.
Derchain, S.
Eržen, M.
Branca, M.
Tatti, S.
Naud, P.
Matos, J. C.
Gontijo, R.
Maeda, Marina Yoshiê Sakamoto
Lima, Temístocles
Costa, S.
Syrjänen, S.
Syrjänen, K.
KeywordsHormonal contraceptives
Cervical intraepithelial lesions
High-risk human papillomavirus
Cohort study
Issue date2011
PublisherKarger AG
JournalGynecologic and Obstetric Investigation
Abstract(s)AIMS: To evaluate the role of hormonal contraceptives as a risk factor of high-risk human papillomavirus (HR-HPV), cervical intraepithelial lesions (CIN) and cervical cancer in our multi-center population-based LAMS (Latin American Screening) study. METHODS: A cohort study with >12,000 women from Brazil and Argentina using logistic regression to analyze the covariates of hormonal contraception (HOC - oral, injections, patches, implants, vaginal ring and progesterone intrauterine system) use followed by multivariate modeling for predictors of HR-HPV and CIN2+. RESULTS: HR-HPV infection was a consistent risk factor of high-grade CIN in all three groups of women. The length of HOC use was not significantly related to high-grade squamous intraepithelial lesions (HSIL)+ Pap (p = 0.069), LSIL+ Pap (p = 0.781) or ASCUS+ (p = 0.231). The same was true with the length of HOC use and histology CIN3+ (p = 0.115) and CIN2+ (p = 0.515). Frequently, HOC users have previously shown more HPV-related lesions, as well as lower HPV prevalence if they were current smokers. But HOC use and time of usage were not independent risk factors of either HR-HPV infection or high-grade CIN using multiple logistic regressions. CONCLUSIONS: No evidence was found for an association between the use of HOC with an increased risk for HR-HPV infection or high-grade CIN in this cohort.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em revistas internacionais / Papers in international journals

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