Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/25591

TitleAlternative methodology for chitin/hydroxyapatite composites using ionic liquids and supercritical fluid technology
Author(s)Silva, Simone Santos
Duarte, Ana Rita C.
Oliveira, Joaquim M.
Mano, J. F.
Reis, R. L.
KeywordsChitin
Hydroxyapatite
Ionic liquids
Supercritical fluid technology
scaffold pores sizing
Composites
salt leaching
controlled pore sizes
Issue dateAug-2013
PublisherSAGE
JournalJournal of Bioactive and Compatible Polymers
Abstract(s)An alternative, green method was used to develop chitin-based biocomposite (ChHA) materials by an integrated strategy using ionic liquids, supercritical fluid drying, and salt leaching. ChHA matrices were produced by dissolving chitin in 1-butyl-methylimidazolium acetate along with salt and/or hydroxyapatite particles and then subsequent drying. The ChHA composite formed had a heterogeneous porous microstructure with 65%–85% porosity and pore sizes in the range of 100–300 µm. The hydroxyapatite was found to be well distributed within the composite structures and had a positive effect in the viability and proliferation of osteoblast-like cells, in vitro. Our findings indicate that these ChHA matrices have potential applications in bone tissue engineering.
TypeArticle
URIhttp://hdl.handle.net/1822/25591
DOI10.1177/0883911513501595
ISSN0883–9115
Publisher versionhttp://jbc.sagepub.com/content/28/5/481
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

Files in This Item:
File Description SizeFormat 
17661-Journal of Bioactive and compatible polymers_ Silva et al 2013.pdf1,32 MBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID