Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/25591

TítuloAlternative methodology for chitin/hydroxyapatite composites using ionic liquids and supercritical fluid technology
Autor(es)Silva, S. S.
Duarte, Ana Rita C.
Oliveira, Joaquim M.
Mano, J. F.
Reis, R. L.
Palavras-chaveChitin
Hydroxyapatite
Ionic liquids
Supercritical fluid technology
DataAgo-2013
EditoraSage
RevistaJournal of Bioactive and Compatible Polymers
Resumo(s)An alternative, green method was used to develop chitin-based biocomposite (ChHA) materials by an integrated strategy using ionic liquids, supercritical fluid drying, and salt leaching. ChHA matrices were produced by dissolving chitin in 1-butyl-methylimidazolium acetate along with salt and/or hydroxyapatite particles and then subsequent drying. The ChHA composite formed had a heterogeneous porous microstructure with 65%–85% porosity and pore sizes in the range of 100–300 µm. The hydroxyapatite was found to be well distributed within the composite structures and had a positive effect in the viability and proliferation of osteoblast-like cells, in vitro. Our findings indicate that these ChHA matrices have potential applications in bone tissue engineering.
Tipoarticle
URIhttp://hdl.handle.net/1822/25591
DOI10.1177/0883911513501595
ISSN0883–9115
Versão da editorahttp://jbc.sagepub.com/content/28/5/481
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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