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|Title:||Alternative methodology for chitin/hydroxyapatite composites using ionic liquids and supercritical fluid technology|
|Author(s):||Silva, Simone Santos|
Duarte, Ana Rita C.
Oliveira, Joaquim M.
Mano, J. F.
Reis, R. L.
Supercritical fluid technology
scaffold pores sizing
controlled pore sizes
|Journal:||Journal of Bioactive and Compatible Polymers|
|Abstract(s):||An alternative, green method was used to develop chitin-based biocomposite (ChHA) materials by an integrated strategy using ionic liquids, supercritical fluid drying, and salt leaching. ChHA matrices were produced by dissolving chitin in 1-butyl-methylimidazolium acetate along with salt and/or hydroxyapatite particles and then subsequent drying. The ChHA composite formed had a heterogeneous porous microstructure with 65%–85% porosity and pore sizes in the range of 100–300 µm. The hydroxyapatite was found to be well distributed within the composite structures and had a positive effect in the viability and proliferation of osteoblast-like cells, in vitro. Our findings indicate that these ChHA matrices have potential applications in bone tissue engineering.|
|Appears in Collections:||3B’s - Artigos em revistas/Papers in scientific journals|
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|17661-Journal of Bioactive and compatible polymers_ Silva et al 2013.pdf||1,32 MB||Adobe PDF||View/Open|