Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/25503

TitleProcess intensification and optimization for hydroxyapatite nanoparticles production
Author(s)Castro, Filipa
Kuhn, Simon
Jensen, Klavs
Ferreira, António
Rocha, F. A.
Vicente, A. A.
Teixeira, J. A.
KeywordsHydroxyapatite
Microreactor
Precipitation
Laminar flow
Segmented flow
Aggregation
Issue date2013
PublisherPergamon-Elsevier Science Ltd
JournalChemical Engineering Science
Abstract(s)Precipitation processes are widely used in industry for the production of particulate solids. Efficient mixing of the reagents is of major importance for the chemical and physical nature of the synthesized particles. Recently, microreactors have been studied to overcome homogeneity problems found when using stirred tank batch reactors. The present work investigated an ultrasonic tubular microreactor for the continuous-flow precipitation of hydroxyapatite (HAp), both in single-phase flow (SPF) and in gas–liquid flow (GLF). HAp nanoparticles were yielded for both configurations under near-physiological conditions of pH and temperature. The as-prepared particles, especially those that were prepared under GLF, show improved characteristics compared to commercial powder or powder obtained in a stirred tank batch reactor. Primary particles are smaller, particle shape is more homogeneous, and the aggregation degree of the particles is lower.
TypeArticle
URIhttp://hdl.handle.net/1822/25503
DOI10.1016/j.ces.2013.01.002
ISSN0009-2509
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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