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TitleTolerance has its limits: how the thymus copes with infection
Author(s)Alves, Cláudio
Nóbrega, Cláudia
Correia-Neves, Margarida
Cell repertoire
Antimicrobial response
Thymic microenvironment
T cell repertoire
Issue date16-Dec-2013
PublisherScience Direct
JournalTrends in Immunology
Abstract(s)The thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture. These features are altered by local infection of the thymus and by the inflammatory mediators that accompany systemic infection. Although once believed to be an immune privileged site, it is now known that antimicrobial responses are recruited to the thymus. Resolving infection in the thymus is important because chronic persistence of microbes impairs the differentiation of pathogen-specific T cells and diminishes resistance to infection. Understanding how these mechanisms contribute to disease susceptibility, particularly in infants with developing T cell repertoires, requires further investigation.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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