Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/25193

TítuloTolerance has its limits : how the thymus copes with infection
AutorAlves, Cláudio
Nóbrega, Cláudia
Correia-Neves, Margarida
Palavras-chaveThymus
Infection
Cell repertoire
Antimicrobial response
Thymic microenvironment
Data16-Dez-2013
EditoraScience Direct
ResumoThe thymus is required for T cell differentiation; a process that depends on which antigens are encountered by thymocytes, the environment surrounding the differentiating cells, and the thymic architecture. These features are altered by local infection of the thymus and by the inflammatory mediators that accompany systemic infection. Although once believed to be an immune privileged site, it is now known that antimicrobial responses are recruited to the thymus. Resolving infection in the thymus is important because chronic persistence of microbes impairs the differentiation of pathogen-specific T cells and diminishes resistance to infection. Understanding how these mechanisms contribute to disease susceptibility, particularly in infants with developing T cell repertoires, requires further investigation.
Tipoarticle
URIhttp://hdl.handle.net/1822/25193
ISSN1471-4906
Versão da editorahttp://www.sciencedirect.com/science/article/pii/S147149061300094X
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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