Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/25178

TitleMultifunctional Compartmentalized Capsules with a Hierarchical Organization from the Nano to the Macro Scales
Author(s)Costa, Rui R.
Castro Otero, Emilio
Arias, F. J.
Rodríguez-Cabello, José Carlos
Mano, J. F.
KeywordsCompartments
Hierarchical organization
Magnetic properties
Multilayers
Polymers
Issue dateMay-2013
PublisherAmerican Chemical Society
JournalBiomacromolecules
Abstract(s)Inspired by the cells’ structure, we present compartmentalized capsules with temperature and magnetic-based responsiveness and hierarchical organization ranging from the nano- to the visible scales. Liquefied alginate macroscopic beads coated with a layer-by-layer (LbL) chitosan/alginate shell served as containers both for model fluorophores and microcapsules, which in their turn encapsulated either another fluorophore or magnetic nanoparticles (MNPs). The microcapsules were coated with a temperature-responsive chitosan/elastin-like recombinamer (ELR) nanostructured shell. By varying the temperature from 25 to 37 °C, the two-hour release of rhodamine encapsulated within the microcapsules and its diffusion through the external compartment decreased from 84% and 71%. The devices could withstand handling and centrifugal stress, with 50% remaining intact at a rotation speed of 2000g. MNPs attributed magnetic responsiveness toward external magnetic fields. Such a customizable system can be envisaged to transport bioactive agents and cells in tissue engineering applications.
TypeArticle
URIhttp://hdl.handle.net/1822/25178
DOI10.1021/bm400527y
ISSN1525-7797
Publisher versionhttp://pubs.acs.org/doi/abs/10.1021/bm400527y
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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