Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/25175

TitleDual stimuli responsive poly(N-isopropylacrylamide) coated chitosan scaffolds for controlled release prepared from a non residue technology
Author(s)Temtem, M.
Barroso, T.
Casimiro, T.
Mano, J. F.
Aguiar Ricardo, Ana
KeywordsBSA
Chitosan
Drug delivery
Ibuprofen
PNIPAAm
Stimuli responsive polymers
Supercritical carbon dioxide
Issue dateJun-2012
PublisherElsevier
JournalJournal of Supercritical Fluids
Abstract(s)biomaterials for delivery of bioactive substances that can be controlled by external stimuli. Herein we report the production of smart partially biodegradable scaffolds that exhibit pH- and temperatureresponsive behavior and their effects on the release of a model protein and a drug of low molecular weight. Chitosan (CHT) scaffolds (pH sensitive) were coated/impregnated with a thermoresponsive polymer, poly(N-isopropylacrylamide) (PNIPAAm), by in situ synthesis of PNIPAAm within CHT micropores. Microarchitectural analysis by scanning electron microscopy and mercury intrusion porosimetry demonstrate that the coating of the pores inner structure could be efficiently achieved without a considerable loss of porosity of native CHT-scaffolds. Two different strategies were used to impregnate the polymeric devices: supercritical fluid impregnation for scaffold uptake with a model low molecular weight drug (ibuprofen) and bulk loading to impregnate a model protein (bovine serum albumin, BSA). The release profiles showed a specific pattern according to pH and temperature. PNIPAAm temperature responsiveness is able to control BSA release but ibuprofen (Ibu) release is only mediated by pH environmental conditions.
TypeArticle
URIhttp://hdl.handle.net/1822/25175
DOI10.1016/j.supflu.2011.10.015
ISSN0896-8446
Publisher versionhttp://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=24&SID=R26mYWbF6MIAgV5us3R&page=1&doc=1
Peer-Reviewedyes
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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