Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/25167
Título: | Porous hydrogels from shark skin collagen crosslinked under dense carbon dioxide atmosphere |
Autor(es): | Silva, S. P. Moreira-Silva, J. Silva, Tiago H. Perez-Martin, R. I. Sotelo, C. G. Mano, J. F. Duarte, Ana Rita C. Reis, R. L. |
Palavras-chave: | Collagen Hydrogels Marine biotechnolgoy Supercritical fluids Tissue engineering marine biotechnology |
Data: | Set-2013 |
Editora: | Wiley |
Revista: | Macromolecular Bioscience |
Resumo(s): | The possibility to fabricate marine collagen porous structures crosslinked with genipin under high pressure carbon dioxide is investigated. Collagen from shark skin is used to prepare prescaffolds by freeze-drying. The poor stability of the structures and low mechanical properties require crosslinking of the structures. Under dense CO2 atmosphere, crosslinking of collagen pre-scaffolds is allowed for 16 h. Additionally, the hydrogels are foamed and the scaffolds obtained present a highly porous structure. In vitro cell culture tests performed with a chondrocyte-like cell line show good cell adherence and proliferation, which is a strong indication of the potential of these scaffolds to be used in tissue cartilage tissue engineering. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/25167 |
DOI: | 10.1002/mabi.201300228 |
ISSN: | 1616-5195 |
Versão da editora: | http://onlinelibrary.wiley.com/doi/10.1002/mabi.201300228/abstract |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | 3B’s - Artigos em revistas/Papers in scientific journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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17649-Pouros hydrogels from shark skin collagen_2013.pdf | 703,72 kB | Adobe PDF | Ver/Abrir |