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TitlePorous hydrogels from shark skin collagen crosslinked under dense carbon dioxide atmosphere
Author(s)Silva, S. P.
Moreira-Silva, J.
Silva, Tiago H.
Perez-Martin, R. I.
Sotelo, C. G.
Mano, J. F.
Duarte, Ana Rita C.
Reis, R. L.
Marine biotechnolgoy
Supercritical fluids
Tissue engineering
marine biotechnology
Issue dateSep-2013
JournalMacromolecular Bioscience
Abstract(s)The possibility to fabricate marine collagen porous structures crosslinked with genipin under high pressure carbon dioxide is investigated. Collagen from shark skin is used to prepare prescaffolds by freeze-drying. The poor stability of the structures and low mechanical properties require crosslinking of the structures. Under dense CO2 atmosphere, crosslinking of collagen pre-scaffolds is allowed for 16 h. Additionally, the hydrogels are foamed and the scaffolds obtained present a highly porous structure. In vitro cell culture tests performed with a chondrocyte-like cell line show good cell adherence and proliferation, which is a strong indication of the potential of these scaffolds to be used in tissue cartilage tissue engineering.
Publisher version
AccessOpen access
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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