Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/25167

TítuloPorous hydrogels from shark skin collagen crosslinked under dense carbon dioxide atmosphere
Autor(es)Silva, S. P.
Moreira-Silva, J.
Silva, Tiago H.
Perez-Martin, R. I.
Sotelo, C. G.
Mano, J. F.
Duarte, Ana Rita C.
Reis, R. L.
Palavras-chaveCollagen
Hydrogels
Marine biotechnolgoy
Supercritical fluids
Tissue engineering
DataSet-2013
EditoraWiley
RevistaMacromolecular Bioscience
Resumo(s)The possibility to fabricate marine collagen porous structures crosslinked with genipin under high pressure carbon dioxide is investigated. Collagen from shark skin is used to prepare prescaffolds by freeze-drying. The poor stability of the structures and low mechanical properties require crosslinking of the structures. Under dense CO2 atmosphere, crosslinking of collagen pre-scaffolds is allowed for 16 h. Additionally, the hydrogels are foamed and the scaffolds obtained present a highly porous structure. In vitro cell culture tests performed with a chondrocyte-like cell line show good cell adherence and proliferation, which is a strong indication of the potential of these scaffolds to be used in tissue cartilage tissue engineering.
Tipoarticle
URIhttp://hdl.handle.net/1822/25167
ISSN1616-5195
Versão da editorahttp://onlinelibrary.wiley.com/doi/10.1002/mabi.201300228/abstract
Arbitragem científicayes
AcessoopenAccess
Aparece nas coleções:3B’s - Artigos em revistas/Papers in scientific journals

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