Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/24901

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dc.contributor.authorLourenço, Bianca do Nascimento-
dc.contributor.authorMarchioli, Giulia-
dc.contributor.authorWelong Song-
dc.contributor.authorReis, R. L.-
dc.contributor.authorBlitterswijk, C. A. van-
dc.contributor.authorKarperien, Marcel-
dc.contributor.authorApeldoorn, Aart van-
dc.contributor.authorMano, J. F.-
dc.date.accessioned2013-07-31T11:29:57Z-
dc.date.available2013-07-31T11:29:57Z-
dc.date.issued2012-
dc.identifier.issn1934-8630por
dc.identifier.urihttp://hdl.handle.net/1822/24901-
dc.description"Published online: 26 July 2012"por
dc.description.abstractSurface wettability and topography are recognized as critical factors influencing cell behavior on biomaterials. So far only few works have reported cell responses on surfaces exhibiting extreme wettability in combination with surface topography. The goal of this work is to study whether cell behavior on superhydrophobic surfaces is influenced by surface topography and polymer type. Biomimetic superhydrophobic rough surfaces of polystyrene and poly(l-lactic acid) with different micro/nanotopographies were obtained from smooth surfaces using a simple phase-separation based method. Total protein was quantified and showed a less adsorption of bovine serum albumin onto rough surfaces as compared to smooth surfaces of the same material. The mouse osteoblastic MC3T3-E1 cell line and primary bovine articular chondrocytes were used to study cell attachment and proliferation. Cells attached and proliferate better in the smooth surfaces. The superhydrophobic surfaces allowed cells to adhere but inhibited their proliferation. This study indicates that surface wettability, rather than polymer type or the topography of the superhydrophobic surfaces, is a critical factor in determining cell behavior.por
dc.language.isoengpor
dc.publisherSpringer por
dc.rightsopenAccesspor
dc.subjectAttachmentpor
dc.subjectBlood compatibilitypor
dc.subjectBonepor
dc.subjectFibronectinpor
dc.subjectInterfacepor
dc.subjectMicrotopographiespor
dc.subjectMorphologypor
dc.subjectOsteoblast adhesionpor
dc.subjectPoly(l-lactic acid)por
dc.subjectProtein adsorptionpor
dc.titleWettability influences cell behavior on superhydrophobic surfaces with different topographiespor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://dx.doi.org/10.1007/s13758-012-0046-6por
dc.commentshttp://www.3bs.uminho.pt/node/17605por
sdum.publicationstatuspublishedpor
degois.publication.firstPage1por
degois.publication.lastPage11por
degois.publication.issue1-4por
degois.publication.titleBiointerphasespor
degois.publication.volume7por
dc.date.updated2013-07-29T13:28:01Z-
dc.identifier.doi10.1007/s13758-012-0046-6-
dc.identifier.pmid22833364por
dc.subject.wosScience & Technologypor
sdum.journalBiointerphasespor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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