Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/24857

TitlePectin-coated chitosan microgels crosslinked on superhydrophobic surfaces for 5-fluorouracil encapsulation
Author(s)Puga, Ana M.
Lima, A. C.
Mano, J. F.
Concheiro, Angel
Alvarez-Lorenzo, Carmen
KeywordsChitosan
Pectin
Superhydrophobic surfaces
Colorectal cancer
Skin cancer
pH-responsive release
Issue dateMay-2013
PublisherElsevier
JournalCarbohydrate polymers
Abstract(s)5-Fluorouracil(5-FU)-loaded chitosan microgels for oral and topical chemotherapy were prepared applying a superhydrophobic surface-based encapsulation technology. Drug-loaded chitosan dispersions were cross-linked and then coated with drug-free chitosan or pectin layers at the solid-air interface in a highly<br>efficient and environment-friendly way. The size of the microgels (with diameters of ca.280 and 557um for the chitosan seeds and pectin-coated microgels respectively) was the lowest obtained until now using similar biomimetic methodologies. The microgels were characterized regarding 5-FU release pro-files in vitro in aqueous media covering the pH range of the gastrointestinal tract, and cytotoxicity against two cancer cell lines sensitive to 5-FU. Owing to their control of 5-FU release in acidic medium, calcium pectinate-coated microgels can be considered as suitable for oral administration. Growth inhibition of cancer cells by 5-FU was greater when incorporated to chitosan microgels; these being potentially useful for treatment of skin and colorectal tumors.
TypeArticle
DescriptionAccepted 31 May 2013
URIhttp://hdl.handle.net/1822/24857
DOI10.1016/j.carbpol.2013.05.091
ISSN0144-8617
Publisher versionhttp://www.sciencedirect.com/science/article/pii/S0144861713005912
Peer-Reviewedyes
AccessRestricted access (UMinho)
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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