Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/24372

TitleRecFinder – a new tool to find phage proteins responsible for host recognition
Author(s)Mucha, Ângela O.
Nóbrega, Franklin Luzia
Santos, Sílvio Roberto Branco
Ferreira, E. C.
Kluskens, Leon
Azeredo, Joana
Issue date2013
PublisherPortuguese Bioinformatics Network
Abstract(s)(Bacterio)phages are bacterial viruses that represent the most abundant and genetically diverse biological entities on the planet [1,2]. The largest virus group, the order Caudovirales (containing 96% of all known phages), has evolved recognition peptides for efficient virus-host interaction [3]. The peptides, usually located at the phage tail fiber, baseplate and other tail proteins mediate recognition and attachment specifically to bacterial cell wall receptors - lipopolysaccharides, teichoic acids, proteins and flagella. These proteins responsible for host recognition and binding (HBP) are macromolecular machines that make the process of infection highly efficient and finely regulated, and most likely play an important role in the evolutionary success of tailed phages. As a result of this specific binding affinity certain phages can only infect certain bacteria, determining in this manner the phage host range [4]. (...)
TypeAbstract
URIhttp://hdl.handle.net/1822/24372
Peer-Reviewedyes
AccessOpen access
Appears in Collections:CEB - Resumos em Livros de Atas / Abstracts in Proceedings

Files in This Item:
File Description SizeFormat 
Recfinder.pdf343,88 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID