Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/24346

TitleTechnological progresses in monoclonal antibody production systems
Author(s)Rodrigues, E.
Costa, A. R.
Henriques, Mariana
Azeredo, Joana
Oliveira, Rosário
Keywordsmonoclonal antibodies
bioreactors
scale-up
cell culture
operation modes
Issue date2010
PublisherJohn Wiley & Sons Ltd
JournalBiotechnology Progress
Abstract(s)Monoclonal antibodies (mAbs) have become vitally important to modern medicine and are currently one of the major biopharmaceutical products in development. However, the high clinical dose requirements of mAbs demand a greater biomanufacturing capacity, leading to the development of new technologies for their large-scale production, with mammalian cell culture dominating the scenario. Although some companies have tried to meet these demands by creating bioreactors of increased capacity, the optimization of cell culture productivity in normal bioreactors appears as a better strategy. This review describes the main technological progresses made with this intent, presenting the advantages and limitations of each production system, as well as suggestions for improvements. New and upgraded bioreactors have emerged both for adherent and suspension cell culture, with disposable reactors attracting increased interest in the last years. Furthermore, the strategies and technologies used to control culture parameters are in constant evolution, aiming at the on-line multiparameter monitoring and considering now parameters not seen as relevant for process optimization in the past. All progresses being made have as primary goal the development of highly productive and economic mAb manufacturing processes that will allow the rapid introduction of the product in the biopharmaceutical market at more accessible prices. © 2010 American Institute of Chemical Engineers Biotechnol. Prog., 2010
Typearticle
URIhttp://hdl.handle.net/1822/24346
DOI10.1002/btpr.348
ISSN8756-7938
e-ISSN1520-6033
Publisher versionhttp://pt.scribd.com/doc/92876647/Technological-Progresses-in-Monoclonal-Antibody-Production-Systems
Peer-Reviewedyes
AccessopenAccess
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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