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TitleDevelopment and characterization of novel alginate-1 based hydrogels as vehicles for bone substitutes
Author(s)Morais, D. S.
Rodrigues, M. A.
Silva, T. I.
Lopes, M. A.
Santos, M.
Santos, J. D.
Botelho, C. M.
KeywordsInjectable bone substitute
Alginate-based hydrogels
Bone regeneration
Physical–chemical characterization
Issue date2013
JournalCarbohydrate Polymers
Abstract(s)In this work three different hydrogels were developed to associate, as vehicles, with the synthetic bone substitute GR-HA. One based on an alginate matrix (Alg); a second on a mixture of alginate and chitosan (Alg/Ch); and a third on alginate and hyaluronate (Alg/HA), using Ca2+ ions as cross-linking agents. The hydrogels, as well as the respective injectable bone substitutes (IBSs), were fully characterized from the physical-chemical point of view. Weight change studies proved that all hydrogels were able to swell and degrade within 72 hours at pH 7.4 and 4.0, being Alg/HA the hydrogel with the highest degradation rate (80%). Rheology studies demonstrated that all hydrogels are non-Newtonian viscoelastic fluids, and injectability tests showed that IBSs presented low maximum extrusion forces, as well as quite stable average forces. In conclusion, the studied hydrogels present the necessary features to be successfully used as vehicles of GR-HA, particularly the hydrogel Alg/HA.
AccessRestricted access (UMinho)
Appears in Collections:CEB - Publicações em Revistas/Séries Internacionais / Publications in International Journals/Series

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