Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/24154
Título: | Sustained remission from depressive-like behavior depends on hippocampal neurogenesis |
Autor(es): | Pinheiro, António Mateus Pinto, Luísa Bessa, J. M. Morais, Mónica Alves, N. D. Monteiro, S. Patrício, P. Almeida, O. F. X. Sousa, Nuno |
Palavras-chave: | Antidepressant Depression Gliogenesis Neurogenesis Stress |
Data: | Jan-2013 |
Editora: | Nature Publishing Group |
Revista: | Translational Psychiatry |
Citação: | Translational Psychiatry (2013) 3, e210; doi:10.1038/tp.2012.141 |
Resumo(s): | Impairment of hippocampal neurogenesis has been associated with the expression of depressive-like symptoms and some studies have suggested neurogenesis as a critical factor in the normalization of behavior by antidepressant (AD) drugs. This study provides robust evidence that ongoing neurogenesis is essential for the maintenance of behavioral homeostasis and that its pharmacological arrest precipitates symptoms commonly found in depressed patients. Further, the incorporation of newly born neurons and astrocytes into the preexisting hippocampal neurocircuitry is shown to be necessary for the spontaneous recovery from the adverse effects of stress and for long-term benefits of AD treatments. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/24154 |
DOI: | 10.1038/tp.2012.141 |
ISSN: | 2158-3188 |
Versão da editora: | http://dx.doi.org/10.1038/tp.2012.141 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Mateus-Pinheiro A_Transl Psy_2013.pdf | Documento principal | 3,57 MB | Adobe PDF | Ver/Abrir |