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TitleNanostructured and thermoresponsive recombinant biopolymer-based microcapsules for the delivery of active molecules
Author(s)Costa, Rui R.
Custódio, Catarina A.
Arias, F. J.
Rodríguez-Cabello, José Carlos
Mano, J. F.
Drug delivery
Protein encapsulation
Tissue engineering
Issue date27-Feb-2013
JournalNanomedicine: Nanotechnology, Biology, and Medicine
CitationCosta R. R., Custódio C. A., Arias F. J., Rodríguez-Cabello J. C., Mano J. F. Nanostructured and thermoresponsive recombinant biopolymer-based microcapsules for the delivery of active molecules, Nanomedicine: Nanotechnology, Biology and Medicine, Vol. In press, pp. Epub ahead of print, doi:10.1016/j.nano.2013.01.013, 2013
Abstract(s)Multilayer capsules conceived at the nano- and microscales are receiving increasing interest due to their potential role as carriers of biomolecules for drug delivery and tissue engineering. Herein we report the construction of microcapsules by the sequential adsorption of chitosan and a biomimetic elastin-like recombinamer into nanostructured layers on inorganic microparticle templates. The release profile of bovine serum albumin, which was studied at 25 and 37 °C, shows higher retention and Fickian diffusion at physiological temperature. The self-assembled multilayers act as a barrier and allowed for sustained release over 14 days. The capsules studied are non-cytotoxic towards L929 cells, thereby suggesting multiple applications in the fields of biotechnology and bioengineering, where high control of the delivery of therapeutics and growth/differentiation factors is required.
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Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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