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TitleHost defense pathways against fungi : the basis for vaccines and immunotherapy
Author(s)Carvalho, Agostinho
Cunha, Cristina
Iannitti, Andrea
Casagrande, Andrea
Bistoni, Francesco
Aversa, Franco
Romani, Luigina
Immune responses,
Issue dateMay-2012
PublisherFrontiers Media
JournalFrontiers in Microbiology
Abstract(s)Fungal vaccines have long been a goal in the fields of immunology and microbiology to counter the high mortality and morbidity rates owing to fungal diseases, particularly in immunocompromised patients. However, the design of effective vaccination formulations for durable protection to the different fungi has lagged behind due to the important differences among fungi and their biology and our limited understanding of the complex host–pathogen interactions and immune responses. Overcoming these challenges is expected to contribute to improved vaccination strategies aimed at personalized efficacy across distinct target patient populations. This likely requires the integration of multifaceted approaches encompassing advanced immunology, systems biology, immunogenetics, and bioinformatics in the fields of fungal and host biology and their reciprocal interactions.
Publisher version
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

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