Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/23821

TitleHost defense pathways against fungi : the basis for vaccines and immunotherapy
Author(s)Carvalho, Agostinho
Cunha, Cristina
Iannitti, Andrea
Casagrande, Andrea
Bistoni, Francesco
Aversa, Franco
Romani, Luigina
KeywordsFungi
Immune responses,
Vaccines
Immunotherapy
Vaccinomics
Issue dateMay-2012
PublisherFrontiers Media
JournalFrontiers in Microbiology
Abstract(s)Fungal vaccines have long been a goal in the fields of immunology and microbiology to counter the high mortality and morbidity rates owing to fungal diseases, particularly in immunocompromised patients. However, the design of effective vaccination formulations for durable protection to the different fungi has lagged behind due to the important differences among fungi and their biology and our limited understanding of the complex host–pathogen interactions and immune responses. Overcoming these challenges is expected to contribute to improved vaccination strategies aimed at personalized efficacy across distinct target patient populations. This likely requires the integration of multifaceted approaches encompassing advanced immunology, systems biology, immunogenetics, and bioinformatics in the fields of fungal and host biology and their reciprocal interactions.
TypeArticle
URIhttp://hdl.handle.net/1822/23821
DOI10.3389/fmicb.2012.00176
ISSN1664-302X
Publisher versionhttp://www.frontiersin.org/Fungi_and_Their_Interactions/10.3389/fmicb.2012.00176/abstract
Peer-Reviewedyes
AccessOpen access
Appears in Collections:ICVS - Artigos em Revistas Internacionais com Referee

Files in This Item:
File Description SizeFormat 
Carvalho A_Front Microbiol. 2012.pdfDocumento principal438,35 kBAdobe PDFView/Open

Partilhe no FacebookPartilhe no TwitterPartilhe no DeliciousPartilhe no LinkedInPartilhe no DiggAdicionar ao Google BookmarksPartilhe no MySpacePartilhe no Orkut
Exporte no formato BibTex mendeley Exporte no formato Endnote Adicione ao seu ORCID