Utilize este identificador para referenciar este registo: http://hdl.handle.net/1822/23807

TítuloZeolite structures loading with an anticancer compound as drug delivery systems
Autor(es)Amorim, Ricardo
Vilaça, Natália
Martinho, Olga
Reis, R. M.
Sardo, Mariana
Rocha, João
Fonseca, António Manuel
Baltazar, Fátima
Neves, Isabel C.
EditoraAmerican Chemical Society (ACS)
RevistaThe Journal of Physical Chemistry C
Resumo(s)Two different structures of zeolites, faujasite (FAU) and Linde type A (LTA), were studied to investigate their suitability for drug delivery systems (DDS). The zeolites in the sodium form (NaY and NaA) were used as hosts for encapsulation of α-cyano-4- hydroxycinnamic acid (CHC). CHC, an experimental anticancer drug, was encapsulated in both zeolites by diffusion in liquid phase. These new drug delivery systems, CHC@zeolite, were characterized by spectroscopic techniques (FTIR, 1H NMR, 13C and 27Al solidstate MAS NMR, and UV−vis), chemical analysis, powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effect of the zeolites and CHC@zeolite drug deliveries on HCT-15 human colon carcinoma cell line viability was evaluated. Both zeolites alone revealed no toxicity to HCT-15 cancer cells. Importantly, CHC@zeolite exhibit an inhibition of cell viability up to 585-fold, when compared to the non-encapsulated drug. These results indicate the potential of the zeolites for drug loading and delivery into cancer cells to induce cell death
DescriçãoThe authors are thankful to Dr. A. S. Azevedo for collecting the powder diffraction data.
Versão da editorahttp://pubs.acs.org/doi/ipdf/10.1021/jp3093868
Arbitragem científicayes
Aparece nas coleções:ICVS - Artigos em Revistas Internacionais com Referee

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Amorim Ricardo_J. Phys. Chem. C 2012 pp.pdfversão postprint1,59 MBAdobe PDFVer/Abrir

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