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|Título:||Zeolite structures loading with an anticancer compound as drug delivery systems|
Reis, R. M.
Fonseca, António Manuel
Neves, Isabel C.
|Editora:||American Chemical Society (ACS)|
|Revista:||The Journal of Physical Chemistry C|
|Resumo(s):||Two different structures of zeolites, faujasite (FAU) and Linde type A (LTA), were studied to investigate their suitability for drug delivery systems (DDS). The zeolites in the sodium form (NaY and NaA) were used as hosts for encapsulation of α-cyano-4- hydroxycinnamic acid (CHC). CHC, an experimental anticancer drug, was encapsulated in both zeolites by diffusion in liquid phase. These new drug delivery systems, CHC@zeolite, were characterized by spectroscopic techniques (FTIR, 1H NMR, 13C and 27Al solidstate MAS NMR, and UV−vis), chemical analysis, powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effect of the zeolites and CHC@zeolite drug deliveries on HCT-15 human colon carcinoma cell line viability was evaluated. Both zeolites alone revealed no toxicity to HCT-15 cancer cells. Importantly, CHC@zeolite exhibit an inhibition of cell viability up to 585-fold, when compared to the non-encapsulated drug. These results indicate the potential of the zeolites for drug loading and delivery into cancer cells to induce cell death|
|Descrição:||The authors are thankful to Dr. A. S. Azevedo for collecting the powder diffraction data.|
|Versão da editora:||http://pubs.acs.org/doi/ipdf/10.1021/jp3093868|
|Aparece nas coleções:||ICVS - Artigos em Revistas Internacionais com Referee|
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|Amorim Ricardo_J. Phys. Chem. C 2012 pp.pdf||versão postprint||1,59 MB||Adobe PDF||Ver/Abrir|