Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/23807
Título: | Zeolite structures loading with an anticancer compound as drug delivery systems |
Autor(es): | Amorim, Ricardo Vilaça, Natália Martinho, Olga Reis, R. M. Sardo, Mariana Rocha, João Fonseca, António Manuel Baltazar, Fátima Neves, Isabel C. |
Data: | Nov-2012 |
Editora: | American Chemical Society (ACS) |
Revista: | The Journal of Physical Chemistry C |
Resumo(s): | Two different structures of zeolites, faujasite (FAU) and Linde type A (LTA), were studied to investigate their suitability for drug delivery systems (DDS). The zeolites in the sodium form (NaY and NaA) were used as hosts for encapsulation of α-cyano-4- hydroxycinnamic acid (CHC). CHC, an experimental anticancer drug, was encapsulated in both zeolites by diffusion in liquid phase. These new drug delivery systems, CHC@zeolite, were characterized by spectroscopic techniques (FTIR, 1H NMR, 13C and 27Al solidstate MAS NMR, and UV−vis), chemical analysis, powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effect of the zeolites and CHC@zeolite drug deliveries on HCT-15 human colon carcinoma cell line viability was evaluated. Both zeolites alone revealed no toxicity to HCT-15 cancer cells. Importantly, CHC@zeolite exhibit an inhibition of cell viability up to 585-fold, when compared to the non-encapsulated drug. These results indicate the potential of the zeolites for drug loading and delivery into cancer cells to induce cell death |
Tipo: | Artigo |
Descrição: | The authors are thankful to Dr. A. S. Azevedo for collecting the powder diffraction data. |
URI: | https://hdl.handle.net/1822/23807 |
DOI: | 10.1021/jp3093868 |
ISSN: | 1932-7447 |
Versão da editora: | http://pubs.acs.org/doi/ipdf/10.1021/jp3093868 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Amorim Ricardo_J. Phys. Chem. C 2012 pp.pdf | versão postprint | 1,59 MB | Adobe PDF | Ver/Abrir |