Please use this identifier to cite or link to this item: http://hdl.handle.net/1822/23719

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dc.contributor.authorCaridade, S. G.-
dc.contributor.authorMerino, Esther G.-
dc.contributor.authorAlves, N. M.-
dc.contributor.authorZea Bermudez, V. de-
dc.contributor.authorBoccaccini, A. R.-
dc.contributor.authorMano, J. F.-
dc.date.accessioned2013-04-16T14:20:23Z-
dc.date.available2013-04-16T14:20:23Z-
dc.date.issued2013-
dc.date.submitted2013-04-
dc.identifier.issn1751-6161por
dc.identifier.urihttp://hdl.handle.net/1822/23719-
dc.description.abstractA newfamilyofbiodegradablepolymer/bioactiveglass(BG)compositematerialshas emergedbasedontheavailabilityofnano-sizedbioactiveparticles.Suchnovelbiocompo- sites canhaveenhancedperformance,intermsofmechanicalpropertiesandbioactivity, and theycanbedesignedtobeusedinboneregenerationapproaches. In thiswork,membranesofchitosan(CTS)andchitosanwithbioactiveglass(BG)both micron andnanosizedparticles(CTS/mBG,CTS/nBG,respectively)werepreparedby solvent casting.Microstructuralandmechanicalpropertieswereevaluatedinorderto compare theeffectsoftheincorporationofmicro(mBG) andnano(nBG)particlesinthe chitosan matrix. In vitro bioactivity testswereperformedtocharacterizetheapatitelayer that isformedonthesurfaceofthematerialafterbeingimmersedinsimulatedbodyfluid (SBF). Thebiomineralizationprocessonthebiomaterialswasalsofollowedusingnon- conventionaldynamicmechanicalanalysis(DMA),bothonlineandoffline.InsuchDMA experiments,thechangeinthestoragemodulus, E0, andthelossfactor,tan d, were measured asafunctionoftheimmersiontimeinSBF.TheresultsdemonstratedthatCTS/ nBG membranespossessenhancedmechanicalpropertiesandhigherbioactivityin comparisonwiththeCTS/mBG membranes.SuchresultssuggestthepotentialofnBGfor the developmentofbioactivecompositesforboneregenerationapplications.por
dc.description.sponsorshipThis work was financially supported by Foundation for Science and Technology (FCT) by the projects PTDC/QUI/69263/2006, PTDC/CTM-BPC/112774/2009 and, through the scholarship SFRH/BD/64601/2009 granted to Sofia G. Caridade. The authors acknowledge Dr D. Mohn and Prof. W. Stark (Em Zurich) for providing the nBG particles used.por
dc.language.isoengpor
dc.publisherElsevierpor
dc.relationinfo:eu-repo/grantAgreement/FCT/5876-PPCDTI/69263/PT-
dc.rightsopenAccesspor
dc.subjectBioactive glasspor
dc.subjectBioactivitypor
dc.subjectBone regeneration.por
dc.subjectDynamic mechanical analysispor
dc.subjectNanocompositespor
dc.titleChitosan membranes containing micro or nano-size bioactive glass particles : evolution of biomineralization followed by in-situ dynamic mechanical analysispor
dc.typearticle-
dc.peerreviewedyespor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S1751616112003244por
dc.commentshttp://www.3bs.uminho.pt/node/17457por
sdum.publicationstatuspublishedpor
oaire.citationStartPage173por
oaire.citationEndPage183por
oaire.citationTitleJournal of the Mechanical Behavior of Biomedical Materialspor
oaire.citationVolume20por
dc.date.updated2013-04-16T13:13:00Z-
dc.identifier.doi10.1016/j.jmbbm.2012.11.012por
dc.identifier.pmid23466499por
dc.subject.wosScience & Technologypor
sdum.journalJournal of the Mechanical Behavior of Biomedical Materialspor
Appears in Collections:3B’s - Artigos em revistas/Papers in scientific journals

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